Vaĭnshteĭn S G, Zvershkhanovskiĭ F A
Farmakol Toksikol. 1984 Nov-Dec;47(6):87-90.
Comparative studies made on 79 male rats indicate that the synthetic antioxidants ionol and dibunol liniment administered intragastrically in a dose of 50 mg/kg for 7 days do not exert any protective effect on gastric mucosa lesions caused by ligation of the pylorus by Shay's method. At the same time the antioxidants had an inhibitory effect on activation of lipid peroxidation in gastric tissues of rats operated on according to Shay. The absence of the protective action of the antioxidants on ulcer formation together with an inhibitory effect on activation of lipid peroxidation in gastric tissues provide no evidence in favor of the leading role of lipid peroxidation during gastric lesion in animals with ligated pylorus.
对79只雄性大鼠进行的比较研究表明，以50毫克/千克的剂量灌胃给予合成抗氧化剂离子醇和二丁基羟基甲苯搽剂7天，对采用谢伊氏法结扎幽门所致的胃黏膜损伤没有任何保护作用。同时，抗氧化剂对按谢伊氏法手术的大鼠胃组织中脂质过氧化的激活有抑制作用。抗氧化剂对溃疡形成缺乏保护作用，同时对胃组织中脂质过氧化激活有抑制作用，这并不支持脂质过氧化在幽门结扎动物胃损伤过程中起主导作用。
