来源于白背叶的三萜及其对一氧化氮生成的抑制活性。
Triterpenoids from the fruits of Aphanamixis polystachya and their inhibitory activities on nitric oxide production.
机构信息
Yunnan Key Laboratory of Southem Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650500, China.
出版信息
Fitoterapia. 2023 Dec;171:105709. doi: 10.1016/j.fitote.2023.105709. Epub 2023 Oct 21.
Nineteen triterpenoids, including five previously unknown (four triucallane-type derivatives and one highly oxidized A, B-seco limonoids), together with fourteen known triterpenoids, were isolated from the fruits of Aphanamixis polystachya. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated their anti-inflammatory activities. The result showed that all compounds inhibit LPS-induced nitric oxide production in RAW264.7 macrophages with their IC value ranging from 95 to 1332 uM, and compound 6 exhibited obvious anti-inflammatory activity comparable to that of the positive control, with IC values of 94.96 uM.
从八角枫科八角枫属植物华瓜木中分离得到 19 个三萜类化合物，包括 5 个新化合物（4 个三萜烷型衍生物和 1 个高度氧化的 A、B-裂环柠檬苦素）和 14 个已知化合物。通过波谱数据分析鉴定了它们的结构。所有化合物都进行了抗炎活性评价，结果表明，所有化合物对 LPS 诱导的 RAW264.7 巨噬细胞一氧化氮的产生均具有抑制活性，IC50 值范围为 95~1332μM，化合物 6 表现出明显的抗炎活性，与阳性对照相当，IC50 值为 94.96μM。
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