从白背叶（Wall.）帕克中提取的两种新型诺木脂素型二萜。
Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker.
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
出版信息
Fitoterapia. 2020 Jan;140:104431. doi: 10.1016/j.fitote.2019.104431. Epub 2019 Nov 20.
Two novel heptanornemoralisin-type diterpenoids nornemoralisins A (1) and B (2), together with two known compounds nemoralisin (3) and nemoralisin A (4), were isolated from the stem bark and leaves of Aphanamixis polystachya (Wall.) R. Parker. Their structures were established through comprehensive analyses of NMR spectroscopic data and high resolution mass spectrometric (HR-ESI-MS) data. The absolute configurations of carbon stereocenters were elucidated by circular dichroism (CD) analyses. The four compounds were tested for their potential cytotoxic effects against ACHN, HeLa, SMMC-7721, and MCF-7 cell lines. Nornemoralisins A (1) and B (2) exhibited significant cytotoxicity on ACHN with an IC value of 13.9 ± 0.8 and 10.3 ± 0.4 μM, respectively, and other compounds failed to reveal obvious cytotoxicity on the tested cell lines, compared to positive control vinblastine (IC, 28.0 ± 0.9 μM).
从白背桐(Aphanamixis polystachya (Wall.) R. Parker)的茎皮和叶中分离得到了两种新型的七烷诺马利辛型二萜类化合物 nornemoralisins A (1) 和 B (2)，以及两种已知化合物 nemoralisin (3) 和 nemoralisin A (4)。通过综合分析 NMR 谱数据和高分辨质谱 (HR-ESI-MS) 数据确定了它们的结构。通过圆二色性 (CD) 分析阐明了碳立体中心的绝对构型。对四种化合物进行了对 ACHN、HeLa、SMMC-7721 和 MCF-7 细胞系的潜在细胞毒性测试。nornemoralisins A (1) 和 B (2) 对 ACHN 表现出显著的细胞毒性，IC 值分别为 13.9 ± 0.8 和 10.3 ± 0.4 μM，而其他化合物在测试的细胞系中未显示出明显的细胞毒性，与阳性对照长春碱 (IC，28.0 ± 0.9 μM) 相比。
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