From the Department of Paediatrics, Máxima Medical Centre, Veldhoven, the Netherlands.
Pediatr Emerg Care. 2021 Dec 1;37(12):e866-e867. doi: 10.1097/PEC.0000000000002472.
We aimed to describe a case of prematurely born infant with accidental sildenafil overdose.
This was a retrospective case report followed with chart and literature review.
A prematurely born infant with moderate bronchopulmonary dysplasia, corrected congenital heart disease, and pulmonary hypertension presented with an accidental sildenafil overdose. Despite the relatively high dose in this medically frail infant and the long elimination half-life of sildenafil in infants, the symptoms of sildenafil overdose in our patient were only mild. After a short and uneventful period of observation in the hospital, the patient was discharged home.
Sildenafil overdose can cause serious symptoms such as hypotension. However, in our case, the sildenafil overdose was well tolerated, even by a young patient with underlying heart and lung disease. We show that choices in the management of sildenafil intoxication can be made based on the knowledge of sildenafil pharmacokinetics in young children.
我们旨在描述一例意外服用西地那非过量的早产儿病例。
这是一项回顾性病例报告，并结合图表和文献复习。
一名患有中度支气管肺发育不良、矫正型先天性心脏病和肺动脉高压的早产儿出现意外西地那非过量。尽管在这个体弱的婴儿中，剂量相对较高，且西地那非在婴儿中的消除半衰期较长，但我们患者的西地那非过量症状仅为轻度。在医院进行了短暂且无并发症的观察后，患者出院回家。
西地那非过量可能会导致严重的症状，如低血压。然而，在我们的病例中，西地那非过量耐受良好，即使是患有潜在心肺疾病的年轻患者也是如此。我们表明，根据对幼儿西地那非药代动力学的了解，可以对西地那非中毒的治疗做出选择。
