Zhu L Y, Chen X, Xu Z Z, Xu L, Mao T, Zhang H
Clin Exp Obstet Gynecol. 2015;42(1):62-6.
This study aims to investigate the number changes and the clinical significance of the peripheral blood T lymphocyte subsets and NK (natural killer) cells in unexplained recurrent spontaneous abortion (URSA) patients before and after abortion, as well as after successful pregnancy.
Thirty-nine URSA patients (URSA-abortion group), among who 22 patients were followed up until the final successful parturition (URSA-pregnancy group), 31 normal-pregnancy (NP) cases and 25 normal non-pregnancy (NNP) control cases in which the peripheral blood T lymphocytes and subsets, B cells, and NK cells were assessed flow cytometry.
Compared with the URSA-pregnancy group and the NP group, the Th cells and NK cells of the URSA-abortion group increased (p < 0.05); compared with the NNP group, the total number of T cells decreased after the first, second, and third month of the URSA abortion (p < 0.05); Th cells decreased within one to six months of the URSA abortion (p < 0.05); proportion of NK cells was significantly higher in URSA patients (p < 0.05).
The abnormal numbers of the peripheral blood T cell subsets and NK cells were related with the occurrence of URSA.
本研究旨在探讨不明原因复发性自然流产（URSA）患者流产前后及成功妊娠后外周血T淋巴细胞亚群和NK（自然杀伤）细胞的数量变化及其临床意义。
选取39例URSA患者（URSA流产组），其中22例患者随访至最终成功分娩（URSA妊娠组），31例正常妊娠（NP）病例和25例正常未妊娠（NNP）对照病例，采用流式细胞术评估外周血T淋巴细胞及其亚群、B细胞和NK细胞。
与URSA妊娠组和NP组相比，URSA流产组的Th细胞和NK细胞增加（p < 0.05）；与NNP组相比，URSA流产后第1、2和3个月T细胞总数减少（p < 0.05）；URSA流产后1至6个月Th细胞减少（p < 0.05）；URSA患者NK细胞比例显著更高（p < 0.05）。
外周血T细胞亚群和NK细胞数量异常与URSA的发生有关。
