Ngo-Nkondjock Raissa Victorine, Yuntao Zhang, Adnan Humara, Adnan Sheikh Muhammad, Cheteu Thérèse Martin Wabo, Li Ying
Harbin Medical University, Department of Nutrition and Food Hygiene, School of Public Health - Harbin - Heilongjiang - China.
Harbin Medical University, Department of Epidemiology and Biostatistics, School of Public Health - Harbin - Heilongjiang - China.
Sleep Sci. 2021 Jan-Mar;14(1):3-10. doi: 10.5935/1984-0063.20200047.
Substantial evidence suggests that the timing of macronutrient intake affects cardiovascular health. The present study aims to assess the association between the dietary carbohydrate intake (DCI) and the high-sensitivity C-reactive protein (hs-CRP) combined with the implication of the chronotype. Thus, we explored the most recently released National Health and Nutrition Examination Survey (NHANES) data. We analysed data from 5,616 participants of the NHANES in 2015. We selected participants with available data for the DCI, sleep and wake-up time, and the hs-CRP. Chronotypes were categorized according to the sleep times. Binary logistic regression analysis was performed to predict participants with low or high levels of hs-CRP based on the DCI and chronotypes. Moderation analysis was used to investigate the effect of the chronotypes on the DCI-hs-CRP's association. A higher DCI was significantly associated with the higher hs-CRP levels (odds ratio (OR) = 1.36, 95% confidence interval (CI) = [0.9-1.8]). Moderate evening (ME) chronotypes had higher risk for high hs-CRP level (OR = 1.15, 95% CI = [1.22-1.23]) compared to the intermediate and the morning chronotypes. The chronotype significantly moderated the hs-CRP given the DCI (moderation coefficient, α2=0.05, 95% CI = [0.01-0.08]). The chronotype diminished the hs-CRP predicted by the DCI. The findings of the study underscore the significance of assessing the protective effect of individuals' chronotype concerning cardiovascular health.
大量证据表明，常量营养素的摄入时间会影响心血管健康。本研究旨在评估膳食碳水化合物摄入量（DCI）与高敏C反应蛋白（hs-CRP）之间的关联，并结合生物钟类型的影响。因此，我们探讨了最新发布的美国国家健康和营养检查调查（NHANES）数据。我们分析了2015年NHANES中5616名参与者的数据。我们选择了有DCI、睡眠时间和唤醒时间以及hs-CRP可用数据的参与者。根据睡眠时间对生物钟类型进行分类。进行二元逻辑回归分析，以根据DCI和生物钟类型预测hs-CRP水平低或高的参与者。采用调节分析来研究生物钟类型对DCI-hs-CRP关联的影响。较高的DCI与较高的hs-CRP水平显著相关（优势比（OR）=1.36，95%置信区间（CI）=[0.9-1.8]）。与中间型和早晨型生物钟类型相比，中度夜晚型（ME）生物钟类型患高hs-CRP水平的风险更高（OR = 1.15，95% CI = [1.22-1.23]）。考虑到DCI，生物钟类型对hs-CRP有显著的调节作用（调节系数，α2 = 0.05，95% CI = [0.01-0.08]）。生物钟类型降低了由DCI预测的hs-CRP。该研究结果强调了评估个体生物钟类型对心血管健康的保护作用的重要性。
