Department of Neurology, Tianjin Union Medical Center, Tianjin, People's Republic of China.
Tianjin Medical University, Tianjin, People's Republic of China.
Nutr Neurosci. 2024 Nov;27(11):1321-1329. doi: 10.1080/1028415X.2024.2329481. Epub 2024 Apr 2.
Epilepsy is a neurological disorder characterized by recurrent seizures. We aimed to investigate the association between the percentage of dietary carbohydrate intake (DCI) and epilepsy prevalence among American adults.
We analyzed the data from 9,584 adults aged 20-80 years who participated in the National Health and Nutrition Examination Survey from 2013 to 2018. Logistic regression was applied to explore the association between the percentage of DCI and epilepsy prevalence.
A total of 146 (1.5%) individuals with epilepsy were enrolled in this study. The average age of the participants was 56.4 years, and 5,454 (56.9%) individuals were female. A high DCI was associated with an increased prevalence of epilepsy (odds ratio [OR], 4.56; 95% confidence interval [CI], 1.11-18.69; = 0.035) after adjusting for age, sex, marital status, race/ethnicity, educational level, family income, body mass index, smoking status, drinking status, hypertension, diabetes, and cardiovascular disease. Stratified analyses indicated a positive correlation between DCI and epilepsy prevalence in adults with different characteristics. Compared with individuals in quartile 1 of DCI (<40.5%), those in quartile 4 (>55.4%) had an adjusted OR for epilepsy of 1.72 (95% CI, 1.09-2.73, = 0.02, P for trend= 0.012).
A high percentage of DCI was associated with an increased prevalence of epilepsy. The risk of epilepsy increased 3.5-fold with a 1% increase in DCI. These results suggest an important role of DCI in the dietary management of epilepsy.
癫痫是一种以反复发作性癫痫发作为特征的神经系统疾病。我们旨在研究美国成年人中膳食碳水化合物摄入量（DCI）百分比与癫痫患病率之间的关系。
我们分析了 2013 年至 2018 年期间参加国家健康和营养检查调查的 9584 名 20-80 岁成年人的数据。应用逻辑回归探讨 DCI 百分比与癫痫患病率之间的关系。
本研究共纳入 146 例（1.5%）癫痫患者。参与者的平均年龄为 56.4 岁，5454 人（56.9%）为女性。在调整年龄、性别、婚姻状况、种族/民族、教育程度、家庭收入、体重指数、吸烟状况、饮酒状况、高血压、糖尿病和心血管疾病后，高 DCI 与癫痫患病率增加相关（比值比[OR]，4.56；95%置信区间[CI]，1.11-18.69；=0.035）。分层分析表明，DCI 与不同特征成年人的癫痫患病率之间存在正相关。与 DCI 第 1 四分位（<40.5%）相比，DCI 第 4 四分位（>55.4%）的成年人癫痫调整后 OR 为 1.72（95%CI，1.09-2.73，=0.02，P 趋势=0.012）。
高 DCI 百分比与癫痫患病率增加相关。DCI 增加 1%，癫痫风险增加 3.5 倍。这些结果表明 DCI 在癫痫饮食管理中具有重要作用。
