Sirot D, Sirot J, Cluzel R, Joly B
Pathol Biol (Paris). 1977 Nov;25(9):605-10.
Miscellaneous Staphylococcus aureus populations were tested with seven commercialized cephalosporins. The strains were divided in five groups according to the following criteria: penicillinase production or not: sensitivity to methicillin and cephalosporins; RB type resistance to methicillin; RH and RO type resistance to every beta-lactamine (according to Chabbert and Baudens). For each cephalosporin studied, the population cell analysis performed with these different groups showed the constant heterogeneous arrangement of the individual MIC. However, whatever the staphylococcus group, cephaloridine remains the antibiotic that inhibits the largest number of cells at lower concentration than other cephalosporins. In vitro results were compared with pharmacokinetic data of the different cephalosporins.
用七种商业化头孢菌素对不同的金黄色葡萄球菌群体进行了测试。根据以下标准将菌株分为五组：是否产生青霉素酶；对甲氧西林和头孢菌素的敏感性；对甲氧西林的RB型耐药性；对每种β-内酰胺的RH和RO型耐药性（根据沙伯特和博登斯的方法）。对于所研究的每种头孢菌素，对这些不同组进行的群体细胞分析显示，个体最低抑菌浓度（MIC）呈持续的异质性分布。然而，无论葡萄球菌属于哪一组，头孢利定仍然是在比其他头孢菌素更低浓度下抑制细胞数量最多的抗生素。将体外实验结果与不同头孢菌素的药代动力学数据进行了比较。
