Yourassowsky E, Schoutens E
Int J Clin Pharmacol Biopharm. 1975 Dec;12(4):433-6.
A total of 30 recently isolated strains of Haemophilus influenzae were tested for in vitro susceptibility to seven cephalosporins. In order of bacteriostatic effectiveness, the in vitro activity of the antibiotics studied was: cephapirin (median MIC = 0.78 mcg/ml), cephalothin (median MIC = 1.56 mcg/ml), cefazolin (median MIC: 1.56 mcg/ml), cephaloridine (median MIC = 3.12 mcg/ml), cefoxitin (median MIC = 3.12 mcg/ml), cephradine (median MIC = 12.5 mcg/ml) and cephalexin (median MIC = 25 mcg/ml). The bactericidal effectiveness of the seven compounds was studied against one of these strains. No drug was able to kill the selected strain in less than 6 hrs, even at 100 mcg per ml. Cefoxitin exhibited the best bactericidal effects, closely followed by cefazolin and cephapirin.
共对30株近期分离出的流感嗜血杆菌进行了七种头孢菌素的体外药敏试验。按抑菌效力排序，所研究抗生素的体外活性依次为：头孢匹林（MIC中位数=0.78微克/毫升）、头孢噻吩（MIC中位数=1.56微克/毫升）、头孢唑林（MIC中位数=1.56微克/毫升）、头孢啶（MIC中位数=3.12微克/毫升）、头孢西丁（MIC中位数=3.12微克/毫升）、头孢拉定（MIC中位数=12.5微克/毫升）和头孢氨苄（MIC中位数=25微克/毫升）。研究了这七种化合物对其中一株菌株的杀菌效力。即使在每毫升100微克的浓度下，也没有一种药物能在不到6小时内杀死所选菌株。头孢西丁表现出最佳的杀菌效果，其次是头孢唑林和头孢匹林。
