Hoppu K, Koskimies O, Vilska J
Children's Hospital, Helsinki, Finland.
Int J Clin Pharmacol Ther Toxicol. 1988 Feb;26(2):65-8.
In the first study to assess the effect of trimethoprim in the treatment of acute urinary tract infections in children, we compared it with sulphisoxazole. Eighteen girls, mean age 5.3 years, were treated with trimethoprim 6 mg/kg/day. Seventeen girls, mean age 5.0 years, treated with sulphisoxazole 150-200 mg/kg/day for 10 days served as controls. All infections were cured. Three patients in each group had reinfections during the 6 months of follow-up. In each group, one of the reinfections occurred within 2 weeks after the end of the treatment. One patient developed a rash from sulphisoxazole and so required drug change. No other adverse effects were observed. We conclude that trimethoprim is as effective as sulphisoxazole in the treatment of simple acute urinary tract infections of children and recommend it, in the dosage used, as an alternative first-choice drug, especially for patients who have had side effects from sulphonamides or nitrofurantoin.
在第一项评估甲氧苄啶治疗儿童急性尿路感染效果的研究中，我们将其与磺胺异噁唑进行了比较。18名平均年龄为5.3岁的女孩接受了6毫克/千克/天的甲氧苄啶治疗。17名平均年龄为5.0岁的女孩接受了150 - 200毫克/千克/天的磺胺异噁唑治疗，为期10天，作为对照。所有感染均被治愈。在随访的6个月中，每组各有3名患者再次感染。每组中，有一次再感染发生在治疗结束后的2周内。一名患者因磺胺异噁唑出现皮疹，因此需要更换药物。未观察到其他不良反应。我们得出结论，甲氧苄啶在治疗儿童单纯性急性尿路感染方面与磺胺异噁唑一样有效，并推荐使用所采用的剂量作为替代首选药物，特别是对于那些对磺胺类药物或呋喃妥因有副作用的患者。
