Seragnoli Federico, Pires Martins Daniel, Thorens Gabriel
Service d'addictologie, HUG, 1211 Genève 14.
Rev Med Suisse. 2021 Jun 9;17(742):1108-1110.
The practice of microdosing, which consists of ingesting a hallucinogen at 5-10% of a dose that would induce a psychedelic effect, has recently been the subject of growing interest by the media. The craze for microdosing has been relayed by the supposed effects of increased performance and creativity reported by professionals, especially in Silicon Valley. Despite this strong public interest, the evidence supporting this practice remains preliminary. Available studies are mostly based on single doses, leaving open the question of a possible stronger effect with regular doses. LSD's main effect is on the serotonin system, in particular on 5-HT2A receptors, a receptor involved in neurobiological processes underlying learning.
微剂量服用，即摄入能产生迷幻效果剂量5%-10%的致幻剂，这种做法近来受到媒体越来越多的关注。微剂量服用的热潮因专业人士，尤其是硅谷人士所报告的其能提高工作效率和创造力的假定效果而得到传播。尽管公众对此兴趣浓厚，但支持这种做法的证据仍属初步。现有研究大多基于单次剂量，常规剂量是否可能产生更强效果这一问题仍未解决。麦角酸二乙酰胺（LSD）的主要作用于血清素系统，尤其是5-HT2A受体，该受体参与学习背后的神经生物学过程。
