自闭症高危婴儿的家长的早期担忧。

Early concerns in parents of infants at risk for autism.

机构信息

David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.

Department of Medicine, University of California, San Francisco, CA, USA.

出版信息

Dev Med Child Neurol. 2021 Dec;63(12):1410-1416. doi: 10.1111/dmcn.14925. Epub 2021 Jun 9.

DOI:10.1111/dmcn.14925

PMID:34109620

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8666093/

Abstract

AIM

To examine parental concerns about children at increased familial risk (i.e. high risk) of developing autism spectrum disorder (ASD) in early infancy.

METHOD

ASD-related and general parental concerns were prospectively collected for 76 infants at ages 1.5, 3, 6, 9, 12, and 18 months. Outcome classification was determined at 36 months. Analyses included generalized linear mixed models and qualitative evaluation of parental concerns in relation to risk status (high vs low risk) and outcome classification within the high-risk group (atypically developing vs typically developing) over time.

RESULTS

Most parents had no concerns at 1.5 (high risk 71%, low risk 87%) and 3 months (high risk 77%, low risk 86%). Beginning at 6 months, parents of high-risk infants reported more ASD-related (p<0.001) and general concerns (p=0.003) than parents of low-risk infants. Beginning at 12 months, parents of high-risk atypically developing infants reported more ASD-related concerns than parents of high-risk typically developing infants (p=0.013).

INTERPRETATION

Clinicians should elicit parental concerns and provide support, as parents are worried about their high-risk infants by age 6 months. Additionally, parents' abilities to identify concerns that are suggestive of ASD by age 12 months may aid in earlier screening and intervention. What this paper adds Most parents did not report concerns during early infancy. By 6 months, parents of high-risk infants reported autism spectrum disorder (ASD)-related and general concerns. By 12 months, parents of high-risk atypically developing infants identified ASD-related concerns.

摘要

目的

探讨具有自闭症谱系障碍（ASD）家族高风险（即高风险）的儿童的父母在婴儿早期对子女的担忧。

方法

前瞻性收集了 76 名 1.5、3、6、9、12 和 18 个月龄婴儿的 ASD 相关和一般父母的担忧。36 个月时确定了结果分类。分析包括广义线性混合模型和父母在风险状况（高风险与低风险）和高风险组（发育异常与发育正常）中的关注问题的定性评估，以及随时间的变化。

结果

大多数父母在 1.5 个月（高风险 71%，低风险 87%）和 3 个月（高风险 77%，低风险 86%）时没有任何担忧。从 6 个月开始，高风险婴儿的父母报告了更多的 ASD 相关（p<0.001）和一般关注（p=0.003），而低风险婴儿的父母则没有。从 12 个月开始，高风险发育异常婴儿的父母比高风险发育正常婴儿的父母报告了更多的 ASD 相关关注（p=0.013）。

解释

临床医生应引起父母的关注并提供支持，因为父母在 6 个月大时就开始担心他们的高风险婴儿。此外，父母在 12 个月大时识别出提示 ASD 的担忧的能力可能有助于早期筛查和干预。本文的补充内容：大多数父母在婴儿早期没有报告担忧。6 个月时，高风险婴儿的父母报告了 ASD 相关和一般关注。12 个月时，高风险发育异常婴儿的父母识别出了 ASD 相关的担忧。