Gopcevic Kristina R, Gkaliagkousi Eugenia, Nemcsik János, Acet Ömür, Bernal-Lopez M Rosa, Bruno Rosa M, Climie Rachel E, Fountoulakis Nikolaos, Fraenkel Emil, Lazaridis Antonios, Navickas Petras, Rochfort Keith D, Šatrauskienė Agnė, Zupkauskienė Jūratė, Terentes-Printzios Dimitrios
Laboratory for Analytics of Biomolecules, Department of Chemistry in Medicine, Faculty of Medicine, Belgrade, Serbia.
3rd Department of Internal Medicine, Papageorgiou Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Front Physiol. 2021 Dec 14;12:789690. doi: 10.3389/fphys.2021.789690. eCollection 2021.
Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.
动脉损伤是持续暴露于各种有害因素的结果，并随时间推移而进展；这是血管衰老所固有的一种现象。氧化应激、炎症、高心血管风险状况下有害物质的积累、细胞外基质的变化和/或分子表观遗传修饰的改变，都是已被证实促成血管衰老的重要病理生理过程，也会导致相关循环分子水平的变化。因此，这些分子中的许多在临床和研究环境中都被视为血管损伤和血管加速衰老的标志物，然而，要将这些分子归类为血管衰老的生物标志物，还必须满足进一步的标准。在本文中，我们进行了一项范围界定文献综述，确定了30种最重要和8种较次要的血管衰老生物标志物。在此，我们概述了与上述病理状况相关的一些最重要的分子，并研究它们作为血管衰老循环生物标志物的效用。
