肯尼亚儿童免疫接种覆盖率的不平等与社会经济、地理、产妇、儿童和出生地点特征有关。

Inequities in childhood immunisation coverage associated with socioeconomic, geographic, maternal, child, and place of birth characteristics in Kenya.

机构信息

Gavi, the Vaccine Alliance, Geneva, Switzerland.

London School of Hygiene and Tropical Medicine, London, UK.

出版信息

BMC Infect Dis. 2021 Jun 11;21(1):553. doi: 10.1186/s12879-021-06271-9.

Abstract

BACKGROUND

The global Immunisation Agenda 2030 highlights coverage and equity as a strategic priority goal to reach high equitable immunisation coverage at national levels and in all districts. We estimated inequities in full immunisation coverage associated with socioeconomic, geographic, maternal, child, and place of birth characteristics among children aged 12-23 months in Kenya.

METHODS

We analysed full immunisation coverage (1-dose BCG, 3-dose DTP-HepB-Hib (diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae type B), 3-dose polio, 1-dose measles, and 3-dose pneumococcal vaccines) of 3943 children aged 12-23 months from the 2014 Kenya Demographic and Health Survey. We disaggregated mean coverage by socioeconomic (household wealth, religion, ethnicity), geographic (place of residence, province), maternal (maternal age at birth, maternal education, maternal marital status, maternal household head status), child (sex of child, birth order), and place of birth characteristics, and estimated inequities in full immunisation coverage using bivariate and multivariate logistic regression.

RESULTS

Immunisation coverage ranged from 82% [81-84] for the third dose of polio to 97.4% [96.7-98.2] for the first dose of DTP-HepB-Hib, while full immunisation coverage was 68% [66-71] in 2014. After controlling for other background characteristics through multivariate logistic regression, children of mothers with primary school education or higher have at least 54% higher odds of being fully immunised compared to children of mothers with no education. Children born in clinical settings had 41% higher odds of being fully immunised compared to children born in home settings. Children in the Coast, Western, Central, and Eastern regions had at least 74% higher odds of being fully immunised compared to children in the North Eastern region, while children in urban areas had 26% lower odds of full immunisation compared to children in rural areas. Children in the middle and richer wealth quintile households were 43-57% more likely to have full immunisation coverage compared to children in the poorest wealth quintile households. Children who were sixth born or higher had 37% lower odds of full immunisation compared to first-born children.

CONCLUSIONS

Children of mothers with no education, born in home settings, in regions with limited health infrastructure, living in poorer households, and of higher birth order are associated with lower rates of full immunisation. Targeted programmes to reach under-immunised children in these subpopulations will lower the inequities in childhood immunisation coverage in Kenya.

摘要

背景

全球免疫议程 2030 强调覆盖范围和公平性是实现国家层面和所有地区高公平免疫覆盖率的战略优先目标。我们评估了肯尼亚 12-23 个月龄儿童在社会经济、地理、产妇、儿童和出生地特征方面与完全免疫覆盖相关的不平等现象。

方法

我们分析了 2014 年肯尼亚人口与健康调查中 3943 名 12-23 个月龄儿童的完全免疫覆盖情况(1 剂卡介苗、3 剂 DTP-HepB-Hib(白喉、破伤风、百日咳、乙型肝炎和流感嗜血杆菌 B 型)、3 剂脊髓灰质炎、1 剂麻疹和 3 剂肺炎球菌疫苗)。我们按社会经济(家庭财富、宗教、族裔)、地理(居住地、省份)、产妇(产妇出生时的年龄、产妇教育程度、产妇婚姻状况、产妇家庭主妇地位)、儿童(儿童性别、出生顺序)和出生地特征对平均覆盖率进行细分,并使用双变量和多变量逻辑回归估计完全免疫覆盖率的不平等情况。

结果

2014 年,脊灰疫苗第三剂的免疫覆盖率为 82%[81-84],而 DTP-HepB-Hib 第一剂的免疫覆盖率为 97.4%[96.7-98.2],而完全免疫覆盖率为 68%[66-71]。通过多变量逻辑回归控制其他背景特征后,接受过小学及以上教育的母亲所生子女完全免疫的几率至少比未接受过教育的母亲所生子女高 54%。在医疗机构出生的儿童完全免疫的几率比在家中出生的儿童高 41%。与东北地区的儿童相比,沿海、西部、中部和东部地区的儿童完全免疫的几率至少高 74%,而与农村地区的儿童相比,城市地区的儿童完全免疫的几率低 26%。中产阶级和较富裕家庭的儿童完全免疫的可能性比最贫穷家庭的儿童高 43-57%。与头胎儿童相比,第六胎及以上出生的儿童完全免疫的几率低 37%。

结论

没有受过教育的母亲所生、在家中出生、在卫生基础设施有限的地区、生活在较贫困家庭和出生顺序较高的儿童,其完全免疫的比例较低。针对这些亚人群中免疫不足儿童的目标计划将降低肯尼亚儿童免疫接种覆盖率的不平等现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c9b/8194194/0beae61fd1ac/12879_2021_6271_Fig1_HTML.jpg

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