Sabater F, Mensa J, Doménech J, Loncá M, Carulla M
Dept. of Otolaryngology, Hospital Clínic of Barcelona.
J Laryngol Otol. 1988 Jul;102(7):606-7. doi: 10.1017/s0022215100105857.
Necrotizing (malignant) external otitis is a severe infection caused by Pseudomonas aeruginosa which occurs mainly in elderly diabetics or in immuno-depressed patients (Chandler, 1968). The management of this condition requires the association between an aminoglycoside antibiotic and an antipseudomonal beta-lactamic, given parenterally during a 4 to 6 week period. Sometimes it is necessary to continue the therapy for months until there is no evidence of residual disease (Strauss et al., 1982). Ciprofloxacin is a quinolone with antipseudomonal activity which can be taken orally, and it is a useful alternative to the current treatment. The authors report a case of necrotizing external otitis which was successfully treated with ciprofloxacin.
坏死性(恶性)外耳道炎是一种由铜绿假单胞菌引起的严重感染,主要发生于老年糖尿病患者或免疫功能低下的患者(钱德勒,1968年)。这种病症的治疗需要将一种氨基糖苷类抗生素与一种抗假单胞菌β-内酰胺类药物联合使用,在4至6周的时间内进行肠胃外给药。有时有必要将治疗持续数月,直到没有残余疾病的迹象(施特劳斯等人,1982年)。环丙沙星是一种具有抗假单胞菌活性的喹诺酮类药物,可口服,是当前治疗方法的一种有用替代药物。作者报告了一例用环丙沙星成功治疗的坏死性外耳道炎病例。