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Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice.MRL/lpr小鼠库普弗细胞自发产生肿瘤坏死因子α
J Exp Med. 1988 Aug 1;168(2):789-94. doi: 10.1084/jem.168.2.789.
2
TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease.肿瘤坏死因子-α增强自身免疫性肾病中集落刺激因子-1诱导的巨噬细胞聚集。
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Kupffer cell tumor necrosis factor-alpha production is suppressed during liver regeneration.在肝脏再生过程中，库普弗细胞的肿瘤坏死因子-α生成受到抑制。
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4
Modulation of murine hepatic lipase activity by exogenous and endogenous Kupffer-cell activation.外源性和内源性库普弗细胞激活对小鼠肝脂肪酶活性的调节作用。
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Autoreactivity accelerates the development of autoimmunity and lymphoproliferation in MRL/Mp-lpr/lpr mice.自身反应性加速了MRL/Mp-lpr/lpr小鼠自身免疫和淋巴细胞增殖的发展。
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7
Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
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8
Accessory function of Kupffer cells in the antigen-specific blastogenic response of an L3T4+ T-lymphocyte clone to Listeria monocytogenes.库普弗细胞在L3T4 + T淋巴细胞克隆对单核细胞增生李斯特菌的抗原特异性母细胞化反应中的辅助功能。
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Increased macrophage colony-stimulating factor in neonatal and adult autoimmune MRL-lpr mice.新生和成年自身免疫性MRL-lpr小鼠中巨噬细胞集落刺激因子增加。
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10
Immunohistochemical studies of intrahepatic tumour necrosis factor alpha in chronic liver disease.慢性肝病中肝内肿瘤坏死因子α的免疫组织化学研究
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本文引用的文献

1
Macrophages as a source of tumoricidal activity (tumor-necrotizing factor).巨噬细胞作为肿瘤杀伤活性（肿瘤坏死因子）的来源。
Infect Immun. 1980 Nov;30(2):523-30. doi: 10.1128/iai.30.2.523-530.1980.
2
Increase in macrophage Ia expression in autoimmune mice: role of the Ipr gene.自身免疫小鼠巨噬细胞Ia表达增加：Ipr基因的作用。
J Immunol. 1982 Sep;129(3):923-5.
3
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.用于细胞生长和存活的快速比色测定法：应用于增殖和细胞毒性测定。
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. doi: 10.1016/0022-1759(83)90303-4.
4
Detection of endotoxin in human blood and demonstration of an inhibitor.人体血液中内毒素的检测及一种抑制剂的证明
J Lab Clin Med. 1970 Jun;75(6):903-11.
5
Murine models of systemic lupus erythematosus.系统性红斑狼疮的小鼠模型。
Adv Immunol. 1985;37:269-390. doi: 10.1016/s0065-2776(08)60342-9.
6
Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.人重组肿瘤坏死因子对中性粒细胞与脐静脉内皮细胞黏附的刺激作用。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8667-71. doi: 10.1073/pnas.82.24.8667.
7
Modulation of endothelial cell hemostatic properties by tumor necrosis factor.肿瘤坏死因子对内皮细胞止血特性的调节作用
J Exp Med. 1986 Mar 1;163(3):740-5. doi: 10.1084/jem.163.3.740.
8
High hepatic natural killer cell activity in murine lupus.小鼠狼疮中肝脏自然杀伤细胞活性较高。
J Exp Med. 1987 Jul 1;166(1):271-6. doi: 10.1084/jem.166.1.271.
9
Cachectin: more than a tumor necrosis factor.恶病质素：不仅仅是一种肿瘤坏死因子。
N Engl J Med. 1987 Feb 12;316(7):379-85. doi: 10.1056/NEJM198702123160705.
10
Enhancement of in vivo immune response by tumor necrosis factor.肿瘤坏死因子对体内免疫反应的增强作用。
J Immunol. 1987 Dec 1;139(11):3676-9.

MRL/lpr小鼠库普弗细胞自发产生肿瘤坏死因子α

Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice.

作者信息

Magilavy D B, Rothstein J L

机构信息

La Rabida Children's Hospital and Research Center, Department of Pediatrics, Chicago, Illinois.

出版信息

J Exp Med. 1988 Aug 1;168(2):789-94. doi: 10.1084/jem.168.2.789.

DOI:10.1084/jem.168.2.789
PMID:3411293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189007/
Abstract

We report that freshly isolated, unstimulated Kupffer cells (KC) from MRL/lpr female mice in short-term culture spontaneously produce high levels of TNF-alpha. TNF production was first detected in KC cultures at age 6 wk and increased with the age of the mice. Moreover, the levels of spontaneous TNF production by KC directly correlated with the age of the MRL/lpr mice. Although TNF production by KC could be induced with C. parvum in vivo or LPS in vitro in all nonautoimmune C3H/HeN, BALB/c, DBA/2, C57B16 mice, the only other strain in which spontaneous TNF production by KC was observed was MRL/++ mice greater than 10 mo old.

摘要

我们报告称，从MRL/lpr雌性小鼠新鲜分离的未受刺激的库普弗细胞（KC）在短期培养中会自发产生高水平的肿瘤坏死因子-α（TNF-α）。TNF的产生在6周龄的KC培养物中首次被检测到，并随着小鼠年龄的增长而增加。此外，KC自发产生TNF的水平与MRL/lpr小鼠的年龄直接相关。虽然在所有非自身免疫性的C3H/HeN、BALB/c、DBA/2、C57B16小鼠中，KC产生TNF可在体内被微小隐孢子虫诱导或在体外被脂多糖诱导，但观察到KC自发产生TNF的唯一其他品系是大于10月龄的MRL/++小鼠。