MRL/lpr小鼠库普弗细胞自发产生肿瘤坏死因子α
Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice.
作者信息
Magilavy D B, Rothstein J L
机构信息
La Rabida Children's Hospital and Research Center, Department of Pediatrics, Chicago, Illinois.
出版信息
J Exp Med. 1988 Aug 1;168(2):789-94. doi: 10.1084/jem.168.2.789.
Abstract
We report that freshly isolated, unstimulated Kupffer cells (KC) from MRL/lpr female mice in short-term culture spontaneously produce high levels of TNF-alpha. TNF production was first detected in KC cultures at age 6 wk and increased with the age of the mice. Moreover, the levels of spontaneous TNF production by KC directly correlated with the age of the MRL/lpr mice. Although TNF production by KC could be induced with C. parvum in vivo or LPS in vitro in all nonautoimmune C3H/HeN, BALB/c, DBA/2, C57B16 mice, the only other strain in which spontaneous TNF production by KC was observed was MRL/++ mice greater than 10 mo old.
摘要
我们报告称，从MRL/lpr雌性小鼠新鲜分离的未受刺激的库普弗细胞（KC）在短期培养中会自发产生高水平的肿瘤坏死因子-α（TNF-α）。TNF的产生在6周龄的KC培养物中首次被检测到，并随着小鼠年龄的增长而增加。此外，KC自发产生TNF的水平与MRL/lpr小鼠的年龄直接相关。虽然在所有非自身免疫性的C3H/HeN、BALB/c、DBA/2、C57B16小鼠中，KC产生TNF可在体内被微小隐孢子虫诱导或在体外被脂多糖诱导，但观察到KC自发产生TNF的唯一其他品系是大于10月龄的MRL/++小鼠。
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