小鼠狼疮中肝脏自然杀伤细胞活性较高。
High hepatic natural killer cell activity in murine lupus.
作者信息
Magilavy D B, Steinberg A D, Latta S L
出版信息
J Exp Med. 1987 Jul 1;166(1):271-6. doi: 10.1084/jem.166.1.271.
Abstract
This study demonstrates a profound elevation of NK activity, as measured by cytotoxicity to YAC-1 targets in a 4-h incubation 51Cr-release assay, of freshly isolated hepatic NPC from both MRL/lpr and (NZB X NZW)F1 mice. This marked increase was not observed in splenic or peripheral blood NK. The hepatic NK were nonadherent, radioresistant, Ly-1-,2-, and AGM1+. Furthermore, biologic response modifiers can further augment hepatic NK activity in these autoimmune strains.
摘要
本研究表明，在4小时孵育的51Cr释放试验中，通过对YAC-1靶标的细胞毒性来测量，来自MRL/lpr和（NZB×NZW）F1小鼠的新鲜分离的肝脏自然杀伤细胞（NK）活性显著升高。在脾脏或外周血NK中未观察到这种显著增加。肝脏NK不黏附、抗辐射、Ly-1-、2-且AGM1+。此外，生物反应调节剂可进一步增强这些自身免疫品系中的肝脏NK活性。
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