Rabin E Z, Jindal S L, Posen G A, Tattrie B, Algom D, Roncari D A, Freedman M, Saunders E F
Proc Eur Dial Transplant Assoc. 1977;14:528-34.
The normal level of serum or plasma poly C-avid ribonuclease activity is 1047 +/- 247 U/mL. Serum levels increase proportionately with elevations in serum creatinine, reaching levels of 9,500-35,000 in patients undergoing dialysis. The levels can be normalised by successful renal transplantation but not by dialysis. Purified human urinary ribonuclease, a glycoprotein enzyme similar to the serum ribonuclease, was capable of: 1) inhibiting the incorporation of 3H-thymidine into mitogen-stimulated lymphocytes; 2) inhibiting the proliferation and growth of bone marrow red cell colonies; and 3) adversely affecting the growth and viability of precursor fat cells.
血清或血浆中多聚 C 亲和核糖核酸酶活性的正常水平为 1047±247 U/mL。血清水平随血清肌酐升高而成比例增加，在接受透析的患者中达到 9500 - 35000 的水平。通过成功的肾移植可使水平恢复正常，但透析则不能。纯化的人尿核糖核酸酶是一种与血清核糖核酸酶相似的糖蛋白酶，它能够：1）抑制 3H - 胸腺嘧啶核苷掺入丝裂原刺激的淋巴细胞；2）抑制骨髓红细胞集落的增殖和生长；3）对前体脂肪细胞的生长和活力产生不利影响。
