Department of Public Health and General Medicine, School of Life Sciences, Anhui University of Chinese Medicine, Hefei, China.
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Rheumatology (Oxford). 2022 Mar 2;61(3):1044-1052. doi: 10.1093/rheumatology/keab479.
To investigate the longitudinal associations of serum inflammatory markers and adipokines with joint symptoms and structures in participants with knee OA.
Two hundred participants (46.5% female, mean age 63.1 years, mean BMI 29.5 kg/m2) from Tasmania, part of the VIDEO (Vitamin D Effect on OA) study, were randomly selected in the current study. Serum levels of 19 biomarkers, scores of WOMAC and MRI-assessed knee structures were evaluated at baseline and month 24. The patterns of biomarkers were derived from principal component analysis and their association with knee symptoms and structures were examined using adjusted generalized estimating equations.
Five components explained 78% of the total variance. IL-1β, -2, -4, -6, -8, -17 A, -17 F, -21, -22 and -23 loaded the highest on the first component, which was associated with increased bone marrow lesions (BMLs) and WOMAC dysfunction score. IL-10, -12 and GM-CSF loaded on the second component, which was associated with increased cartilage volume, and decreased effusion synovitis and WOMAC scores. Leptin, adipsin and CRP loaded on the third component, which was positively associated with WOMAC scores. Resistin loaded on the fourth component, which was associated with increased BMLs and cartilage defects. Apelin-36 and adiponectin loaded on the fifth component, which was associated with increased BMLs.
Various inflammatory and metabolic components were associated differently with joint symptoms and structural changes in knee OA, suggesting a complex inflammatory and metabolic interrelationship in the pathogenesis of knee OA.
研究血清炎症标志物和脂肪因子与膝骨关节炎患者关节症状和结构的纵向关联。
本研究随机选取了来自塔斯马尼亚州 VIDEO（维生素 D 对骨关节炎的影响）研究的 200 名参与者（46.5%为女性，平均年龄 63.1 岁，平均 BMI 为 29.5kg/m2）。在基线和 24 个月时评估了 19 种生物标志物的血清水平、WOMAC 评分和 MRI 评估的膝关节结构。使用调整后的广义估计方程，对生物标志物的模式及其与膝关节症状和结构的关系进行了研究。
五个成分解释了 78%的总方差。IL-1β、-2、-4、-6、-8、-17A、-17F、-21、-22 和 -23 在第一个成分上的负荷最高，该成分与骨髓病变（BMLs）和 WOMAC 功能评分增加有关。IL-10、-12 和 GM-CSF 加载在第二个组件上，与增加的软骨体积、减少的渗出性滑膜炎和 WOMAC 评分降低有关。瘦素、 adiposin 和 CRP 加载在第三个组件上，与 WOMAC 评分增加有关。抵抗素加载在第四个组件上，与 BMLs 增加和软骨缺陷有关。Apelin-36 和 adiponectin 加载在第五个组件上，与 BMLs 增加有关。
各种炎症和代谢成分与膝骨关节炎的关节症状和结构变化的相关性不同，这表明膝骨关节炎发病机制中的炎症和代谢之间存在复杂的相互关系。
