Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano.
Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy.
Medicine (Baltimore). 2021 Jun 11;100(23):e26089. doi: 10.1097/MD.0000000000026089.
COVID-19 presentation is multifaceted and up to 44% of patients affected by COVID-19 experience musculoskeletal complaints, mostly in the form of diffuse aspecific arthromyalgias. Nevertheless, only a few cases of arthritis following SARS-CoV2 infection are reported.
A 27-year-old man affected by nail psoriasis presented with monoarthritis 2 weeks after being diagnosed with COVID-19.
Diagnostic work-up and differential diagnosis were made difficult by patient isolation, absence of lab tests, and his visit via telemedicine, even though signs of first metacarpophalangeal joint involvement were clear.
Due to the inefficacy of acetaminophen and nonsteroidal anti-inflammatory drugs, the patient was prescribed oral steroids with a rapid benefit.
The patient's response to oral steroid was prompt and maintained even after therapy tapering. Even so, a formal diagnosis was not possible due to a difficult diagnostic work-up and lack of a long-term follow-up.
Like many other viral diseases, SARS-CoV2 can play as a causative agent or as a trigger for inflammatory arthritis development in predisposed individuals.
COVID-19 的表现形式多种多样,多达 44%的 COVID-19 患者出现肌肉骨骼投诉,主要表现为弥漫性非特异性关节痛。然而,目前仅报道了少数几例 SARS-CoV2 感染后出现的关节炎病例。
一位 27 岁男性,患有指甲银屑病,在 COVID-19 确诊后 2 周出现单关节炎。
由于患者处于隔离状态,缺乏实验室检查,且通过远程医疗就诊,使得诊断工作和鉴别诊断变得复杂,尽管第一掌指关节受累的迹象明显。
由于乙酰氨基酚和非甾体抗炎药无效,患者开始口服类固醇治疗,迅速获益。
尽管治疗逐渐减少,但患者对口服类固醇的反应迅速且持续。即便如此,由于诊断工作困难且缺乏长期随访,无法做出明确诊断。
与许多其他病毒疾病一样,SARS-CoV2 可作为有发病倾向个体炎症性关节炎发展的致病因子或触发因素。