Department of Clinical Mycobacteriology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki.
Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association.
Medicine (Baltimore). 2021 Jun 11;100(23):e26249. doi: 10.1097/MD.0000000000026249.
The experience and causes of pain in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) have not been clarified.This study aimed to determine the prevalence and severity of bodily pain (BP) in patients with NTM-PD. We also investigated the clinical indicators that contribute to pain.We used a retrospective cross-sectional study design. The participants were 114 NTM-PD patients (109 women) with a mean age of 65 years. The prevalence and severity of pain were measured using 2 items from the 36-Item Short Form Survey version 2 (SF-36), and the BP score was calculated. Functional limitation due to dyspnea was quantified using the Modified Medical Research Council Dyspnea Scale (mMRC), depression was assessed using the Center for Epidemiological Studies Depression Scale (CES-D), sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); health-related quality of life was assessed using the Leicester Cough Questionnaire (LCQ), and exercise tolerance was measured using the Incremental Shuttle Walk Test (ISWT).Pain was reported by 70.2% of the patients (n = 80), and of these, 35.7% (n = 25) reported moderate to very severe pain. NTM-PD patients with high levels of pain had significantly higher scores on the mMRC, CES-D, and PSQI scores, and significantly lower performance on the ISWT and LCQ. Multiple regression analysis identified ISWT, CES-D, and PSQI as independent factors that affected BP scores.Our findings suggest that pain significantly impacts daily life associated with reduced exercise tolerance, the presence of depressive symptoms, and poor sleep quality in patients with NTM-PD.
非结核分枝杆菌肺病（NTM-PD）患者的疼痛体验和原因尚不清楚。本研究旨在确定 NTM-PD 患者躯体疼痛（BP）的患病率和严重程度。我们还研究了导致疼痛的临床指标。我们使用回顾性横断面研究设计。参与者为 114 名 NTM-PD 患者（109 名女性），平均年龄为 65 岁。使用 36-Item Short Form Survey version 2（SF-36）的 2 个项目测量疼痛的患病率和严重程度，并计算 BP 评分。使用改良医学研究委员会呼吸困难量表（mMRC）量化呼吸困难导致的功能受限，使用流行病学研究中心抑郁量表（CES-D）评估抑郁，使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量；使用莱斯特咳嗽问卷（LCQ）评估健康相关生活质量，使用递增穿梭步行测试（ISWT）测量运动耐量。70.2%的患者（n=80）报告有疼痛，其中 35.7%（n=25）报告有中度至非常严重的疼痛。疼痛程度较高的 NTM-PD 患者在 mMRC、CES-D 和 PSQI 评分上的得分明显更高，在 ISWT 和 LCQ 上的得分明显更低。多元回归分析确定 ISWT、CES-D 和 PSQI 是影响 BP 评分的独立因素。我们的研究结果表明，疼痛显著影响患者的日常生活，导致运动耐量降低、存在抑郁症状和睡眠质量差。
