Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Aging (Albany NY). 2021 Jun 13;13(12):16062-16071. doi: 10.18632/aging.203134.
Neural stem cells play pivotal roles during prenatal development and throughout life. Here, we report that Paired immunoglobulin-like receptor B (PirB) functions as a suppressor during brain neurogenesis in the adult mouse. PirB expression increased with age during development, and its deficiency promoted neural stem cell proliferation and differentiation and . Furthermore, we detected an increase in Type 1 neural stem cells in PirB-deficient mice compared to their wild-type littermates. PirB deficiency promoted stemness marker gene expression of Sox2 and KLF4 by activating Akt1 phosphorylation. These findings suggest that PirB inhibits the self-renewal and differentiation capacities of neural stem cells. Thus, PirB may have the potential to serve as a therapeutic target for treatment of reduced neurogenesis in adults due to aging or other pathological conditions.
神经干细胞在胚胎发育和整个生命过程中发挥着关键作用。在这里，我们报告配对免疫球蛋白样受体 B (PirB) 在成年小鼠的大脑神经发生中作为一种抑制因子发挥作用。PirB 的表达在发育过程中随年龄增长而增加，其缺乏促进神经干细胞的增殖和分化。此外，我们发现在 PirB 缺陷型小鼠中，与野生型同窝仔相比，1 型神经干细胞增加。PirB 缺乏通过激活 Akt1 磷酸化来促进 Sox2 和 KLF4 等干性标记基因的表达。这些发现表明 PirB 抑制神经干细胞的自我更新和分化能力。因此，PirB 可能有潜力成为治疗因衰老或其他病理条件导致的成年人神经发生减少的治疗靶点。
