Li Yuanpei, Xiao Kai, Zhu Wei, Deng Wenbin, Lam Kit S
Department of Biochemistry & Molecular Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA.
Department of Biochemistry & Molecular Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA.
Adv Drug Deliv Rev. 2014 Feb;66:58-73. doi: 10.1016/j.addr.2013.09.008. Epub 2013 Sep 21.
Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.
刺激响应性交联胶束（SCMs）是一种用于癌症药物递送的理想纳米载体系统。与非交联的对应物相比，SCMs具有卓越的结构稳定性。因此，这些纳米载体能够最大程度减少血液循环过程中的药物过早释放。环境敏感型交联剂或组装单元的引入使SCMs能够响应肿瘤局部微环境中存在的单一或多种刺激，或外源性施加的刺激。在这些情况下，通过增强的渗透和滞留效应或受体介导的内吞作用积累后，负载的药物几乎仅在癌组织或癌细胞中释放。在本综述中，我们重点介绍了用于癌症治疗的SCMs开发的最新进展。我们还介绍了用于表征SCMs与血液蛋白之间相互作用的最新生物物理技术，如电子顺磁共振（EPR）光谱和荧光共振能量转移（FRET）。
