Singh Aastha, Sangwan Virender S
Department of Cornea, Anterior Segment and Uveitis, Dr. Shroff's Charity Eye Hospital, New Delhi, India.
Front Med (Lausanne). 2021 May 28;8:673330. doi: 10.3389/fmed.2021.673330. eCollection 2021.
Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, the technique has been performed in a variety of cases of limbal stem cell deficiency (LSCD) and has underwent several innovative modifications. Published literature on SLET has progressively increased over time and successful outcomes in various clinical scenarios have been reported. This concise review attempts to present a crisp account of SLET covering the indications and contraindications of performing the procedure; detailed account of pre-operative work up and preparation; surgical technique and its modifications; post-operative course, care and possible complications as well as published outcomes of surgery from across the world. Comparative analysis of various techniques of LSCT have been discussed and common concerns of surgeons practising or those who are planning to start practising SLET have been addressed. The authors hope that the pragmatic insights and pearls given at the end of the review will aid the surgeons in performing this technique to provide maximum benefit to patients suffering from the potentially blinding condition of LSCD.
单纯角膜缘上皮移植术（SLET）是一种巧妙、低成本且有效的角膜缘干细胞移植（LSCT）技术，在全球范围内的实际应用中越来越多地被采用。自十年前首次被描述以来，该技术已应用于多种角膜缘干细胞缺乏症（LSCD）病例，并经历了多次创新性改进。随着时间的推移，关于SLET的已发表文献逐渐增多，并且已有各种临床场景下的成功结果报道。这篇简要综述试图清晰地阐述SLET，涵盖该手术的适应证和禁忌证；术前检查和准备的详细说明；手术技术及其改进；术后过程、护理和可能的并发症，以及来自世界各地的手术已发表结果。文中还讨论了各种LSCT技术的比较分析，并解决了从事SLET手术或计划开始从事SLET手术的外科医生的常见问题。作者希望综述结尾给出的实用见解和要点将有助于外科医生实施该技术，从而为患有可能致盲的LSCD疾病的患者提供最大益处。
