CRISPReader系统检测Ets-1转录因子能够有效识别癌细胞。
CRISPReader System Sensing the Ets-1 Transcription Factor Can Effectively Identify Cancer Cells.
作者信息
Yang Kang, Zhou Yan, Zhong Hongcai
机构信息
HuiZhou Municipal Central Hospital, Huizhou, China.
Logistics Management Office, HuiZhou University, Huizhou, China.
出版信息
Front Mol Biosci. 2021 May 28;8:672040. doi: 10.3389/fmolb.2021.672040. eCollection 2021.
By targeting key genes, the CRISPR system can effectively exert its anti-cancer activity. The latest research suggests that the CRISPReader system that regulates gene transcription can effectively target and inhibit bladder cancer cells by sensing transcription factors such as c-Myc and Get-1 in the cell. An interesting question is whether the CRISPReader system can exert its anti-cancer ability against a variety of tumors by sensing the broad-spectrum transcription factor Ets-1. In this work, a CRISPReader system that senses the Ets-1 transcription factor has been constructed. It can effectively identify a variety of cancer cell lines, and specifically induce apoptosis in cancer cells. This study fully confirmed the effectiveness of Ets-1 as a broad-spectrum cancer related signal and provided a new anti-cancer tool based on the CRISPReader system.
通过靶向关键基因，CRISPR系统可以有效地发挥其抗癌活性。最新研究表明，调节基因转录的CRISPReader系统可以通过感知细胞中的转录因子如c-Myc和Get-1来有效靶向并抑制膀胱癌细胞。一个有趣的问题是，CRISPReader系统是否可以通过感知广谱转录因子Ets-1来发挥其对多种肿瘤的抗癌能力。在这项工作中，构建了一种感知Ets-1转录因子的CRISPReader系统。它可以有效地识别多种癌细胞系，并特异性地诱导癌细胞凋亡。本研究充分证实了Ets-1作为广谱癌症相关信号的有效性，并提供了一种基于CRISPReader系统的新型抗癌工具。
Zotero 插件