Jung Dong Hyuk, Lee Yong Jae, Park Byoungjin
Department of Family Medicine, Yongin Severance Hospital, Yongin, South Korea.
Department of Family Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Front Cardiovasc Med. 2021 May 28;8:677040. doi: 10.3389/fcvm.2021.677040. eCollection 2021.
An increased hemoglobin (Hb) level may have detrimental effects on hepatic steatosis (HS) as well as cardiovascular disease (CVD). We investigated Hb's effect on incident ischemic heart disease (IHD) risk in the context of hepatic steatosis (HS). We assessed 17,521 non-diabetic participants and retrospectively screened for IHD using the Korea National Health Insurance data. High Hb was defined as Hb levels ≥16.3 g/dL in men and 13.9 g/dL in women (>75th percentile). The participants were divided into five groups: reference (group 1), mild HS only (group 2), mild HS and high Hb (group 3), severe HS only (group 4), and severe HS and high Hb (group 5). We assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazards regression models over 50 months from the baseline survey. During the follow-up period, 330 (1.9%) participants developed IHD (310 angina pectoris and 20 myocardial infarction). Compared with the reference group (group 1), the HRs for IHD were 1.04 (95% CI, 0.75-1.46) in group 2, 1.14 (95% CI, 0.70-1.85) in group 3, 1.58 (95% CI, 1.08-2.32) in group 4, and 1.79 (95% CI, 1.15-2.80) in group 5, after adjusting for IHD risk factors. We found the combined effect of HS and Hb levels on the incidence of IHD.
血红蛋白（Hb）水平升高可能对肝脂肪变性（HS）以及心血管疾病（CVD）产生有害影响。我们在肝脂肪变性（HS）的背景下研究了Hb对缺血性心脏病（IHD）发病风险的影响。我们评估了17521名非糖尿病参与者，并使用韩国国民健康保险数据对IHD进行回顾性筛查。高Hb定义为男性Hb水平≥16.3 g/dL，女性≥13.9 g/dL（>第75百分位数）。参与者被分为五组：参照组（第1组）、仅轻度HS组（第2组）、轻度HS和高Hb组（第3组）、仅重度HS组（第4组）以及重度HS和高Hb组（第5组）。我们使用多变量Cox比例风险回归模型，在基线调查后的50个月内评估IHD的风险比（HRs）及95%置信区间（CIs）。在随访期间，330名（1.9%）参与者发生了IHD（310例心绞痛和20例心肌梗死）。与参照组（第1组）相比，在调整IHD危险因素后，第2组IHD的HR为1.04（95%CI，0.75 - 1.46），第3组为1.14（95%CI，0.70 - 1.85），第4组为1.58（95%CI，1.08 - 2.32），第5组为1.79（95%CI，1.15 - 2.80）。我们发现了HS和Hb水平对IHD发病率的联合影响。
