Notch信号通路：新冠病毒病理生理学与其心血管并发症之间的联系
The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications.
作者信息
Breikaa Randa M, Lilly Brenda
机构信息
Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States.
Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH, United States.
出版信息
Front Cardiovasc Med. 2021 May 26;8:681948. doi: 10.3389/fcvm.2021.681948. eCollection 2021.
COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
新冠病毒病（COVID-19）与大量心血管后遗症相关，包括心律失常、心肌损伤、心肌炎和血栓形成。Notch信号通路可能是导致这些并发症的罪魁祸首之一，因为它在病毒进入、炎症和凝血过程中具有直接作用，而这些过程均被证明是COVID-19发病机制的关键部分。本综述重点介绍了严重急性呼吸综合征冠状病毒2（SARS-CoV2）的病理生理学与Notch信号通路之间的联系，这些联系是COVID-19患者心血管并发症的主要驱动因素。
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