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羟基自由基是体内氧化 DNA 损伤的重要参与者。

Hydroxyl radical is a significant player in oxidative DNA damage in vivo.

机构信息

Department of Biochemistry, National University of Singapore, Centre for Life Sciences, #05-01A, 28 Medical Drive, 117456, Singapore.

出版信息

Chem Soc Rev. 2021 Aug 7;50(15):8355-8360. doi: 10.1039/d1cs00044f. Epub 2021 Jun 15.

DOI:10.1039/d1cs00044f
PMID:34128512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8328964/
Abstract

Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO˙) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.

摘要

最近的出版物表明，羟自由基（˙OH）介导的氧化 DNA 损伤在体内并不重要，而碳酸盐阴离子自由基（CO˙）起着关键作用。我们检查了这些说法，并总结了证据，证明 ˙OH 确实作为体内活性氧（ROS）的重要成员发挥了关键作用。

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本文引用的文献

[1]
The Multifaceted Regulation of Mitochondria in Ferroptosis.

Life (Basel). 2021-3-10

[2]
On the relevance of hydroxyl radical to purine DNA damage.

Free Radic Res. 2021-4

[3]
Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability.

DNA Repair (Amst). 2021-1

[4]
The enzyme-modified comet assay: Past, present and future.

Food Chem Toxicol. 2021-1

[5]
Reflections of an aging free radical.

Free Radic Biol Med. 2020-12

[6]
On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics.

Chem Soc Rev. 2020-9-21

[7]
Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical.

Chem Commun (Camb). 2020-8-25

[8]
Oxidative Stress in Cancer.

Cancer Cell. 2020-8-10

[9]
The Fe(citrate) Fenton reaction under physiological conditions.

J Inorg Biochem. 2020-5

[10]
Ultrafast Processes Occurring in Radiolysis of Highly Concentrated Solutions of Nucleosides/Tides.

Int J Mol Sci. 2019-10-8

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