Stenius B, Salorinne Y, Parrott D
Scand J Respir Dis. 1978 Apr;59(2):75-81.
The effect of 71 oxo-7-thiomethoxyxanthone-2-carboxylic acid sodium salt (RS 7540) in inhibiting exercise-induced asthma was compared with that of placebo in a double-blind crossover study. Single doses of 40 mg were given by inhalation to 12 patients. Ten of these subsequently received a dose of 20 mg. RS 7540 at both dose levels had a statistically significant effect in giving total or partial protection from exercise-induced bronchospasm; however, no dose relationship was apparent.
在一项双盲交叉研究中，比较了71-氧代-7-硫代甲氧基呫吨酮-2-羧酸钠盐（RS 7540）与安慰剂对运动诱发性哮喘的抑制作用。对12名患者进行单次吸入40mg剂量给药。其中10名患者随后接受了20mg剂量给药。两个剂量水平的RS 7540在给予运动诱发性支气管痉挛完全或部分保护方面具有统计学显著效果；然而，未发现明显的剂量关系。
