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甘氨酰-L-谷氨酰胺对猫节前去神经支配的颈上神经节中乙酰胆碱酯酶分子形式的体内维持作用。

Maintenance by glycyl-L-glutamine in vivo of molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.

作者信息

Koelle G B, Skau K A, Thampi N S, Hymel D M, Han M S

机构信息

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6084.

出版信息

Proc Natl Acad Sci U S A. 1988 Aug;85(16):6215-7. doi: 10.1073/pnas.85.16.6215.

DOI:10.1073/pnas.85.16.6215
PMID:3413090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281936/
Abstract

The 24-hr intracarotid infusion of plasma-treated glycyl-L-glutamine (3 microM) produced significant enhancement of the monomeric G1 and tetrameric G4 forms of acetylcholinesterase of the cat superior cervical ganglion 48 hr after denervation, in comparison with denervated, noninfused controls. No significant effect of glycyl-L-glutamine could be demonstrated 4 or 6 days after denervation. These findings are consistent with the conclusion, drawn from a previous in vitro study, that glycyl-L-glutamine acts at a stage prior to the aggregation of the G1 form into higher polymers to maintain the acetylcholinesterase content of denervated ganglia. It is proposed that the dipeptide may regulate the transcription of the DNA for acetylcholinesterase to its corresponding mRNA.

摘要

与去神经但未输注的对照组相比，在去神经48小时后，经血浆处理的甘氨酰-L-谷氨酰胺（3微摩尔）进行24小时颈内动脉输注，可显著增强猫颈上神经节乙酰胆碱酯酶的单体G1和四聚体G4形式。去神经4天或6天后，未显示甘氨酰-L-谷氨酰胺有显著作用。这些发现与先前体外研究得出的结论一致，即甘氨酰-L-谷氨酰胺在G1形式聚合成更高聚合物之前的阶段起作用，以维持去神经节中乙酰胆碱酯酶的含量。有人提出，该二肽可能将乙酰胆碱酯酶的DNA转录调节为其相应的信使核糖核酸。

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1
Maintenance by glycyl-L-glutamine in vivo of molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.甘氨酰-L-谷氨酰胺对猫节前去神经支配的颈上神经节中乙酰胆碱酯酶分子形式的体内维持作用。
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6215-7. doi: 10.1073/pnas.85.16.6215.
2
Effects of glycyl-L-glutamine in vitro on the molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.甘氨酰-L-谷氨酰胺体外对猫节前去神经支配的颈上神经节中乙酰胆碱酯酶分子形式的影响。
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5
Direct neurotrophic action of glycyl-L-glutamine in the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.甘氨酰-L-谷氨酰胺对猫节前去神经支配的颈上神经节中乙酰胆碱酯酶和丁酰胆碱酯酶维持的直接神经营养作用。
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6
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引用本文的文献

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Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl phosphorofluoridate administration.甘氨酰-L-谷氨酰胺对大鼠腓肠肌注射二异丙基氟磷酸酯后乙酰胆碱酯酶再生速率的影响。
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本文引用的文献

1
Electron microscope localization of acetylcholinesterase and butyrylcholinesterase in the superior cervical ganglion of the cat. II. Preganglionically denervated ganglion.猫颈上神经节中乙酰胆碱酯酶和丁酰胆碱酯酶的电子显微镜定位。II. 节前神经切断的神经节
J Cell Biol. 1981 Mar;88(3):581-90. doi: 10.1083/jcb.88.3.581.
2
Heavy isotope-labeling study of the metabolism of monomeric and tetrameric acetylcholinesterase forms in the murine neuronal-like T 28 hybrid cell line.小鼠神经元样T 28杂交细胞系中单体和四聚体乙酰胆碱酯酶形式代谢的重同位素标记研究
J Biol Chem. 1984 Mar 25;259(6):3703-13.
3
Effects of sodium pentobarbital anesthesia and neurotrophic factor on the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.戊巴比妥钠麻醉和神经营养因子对猫节前去神经支配的颈上神经节中乙酰胆碱酯酶和丁酰胆碱酯酶维持的影响。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):6122-5. doi: 10.1073/pnas.80.19.6122.
4
The actions of thyroid hormones mediated via the cell nucleus and their clinical significance.甲状腺激素通过细胞核介导的作用及其临床意义。
Clin Endocrinol Metab. 1983 Mar;12(1):101-15. doi: 10.1016/s0300-595x(83)80031-0.
5
Demonstration of a neurotrophic factor for the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.猫颈上神经节节前去神经支配后维持乙酰胆碱酯酶和丁酰胆碱酯酶的神经营养因子的证明。
Proc Natl Acad Sci U S A. 1983 May;80(10):3106-10. doi: 10.1073/pnas.80.10.3106.
6
Partial characterization of the neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo.体内猫颈上神经节节前去神经支配后维持乙酰胆碱酯酶和丁酰胆碱酯酶的神经营养因子的部分特性
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6539-42. doi: 10.1073/pnas.81.20.6539.
7
Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo.甘氨酰-L-谷氨酰胺（一种前体）和甘氨酰-L-谷氨酸（一种神经营养因子，用于在体内维持猫的节前去神经支配的颈上神经节中的乙酰胆碱酯酶和丁酰胆碱酯酶）。
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5213-7. doi: 10.1073/pnas.82.15.5213.
8
Distributions of molecular forms of acetylcholinesterase and butyrylcholinesterase in nervous tissue of the cat.猫神经组织中乙酰胆碱酯酶和丁酰胆碱酯酶分子形式的分布
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7749-52. doi: 10.1073/pnas.84.21.7749.
9
Direct neurotrophic action of glycyl-L-glutamine in the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.甘氨酰-L-谷氨酰胺对猫节前去神经支配的颈上神经节中乙酰胆碱酯酶和丁酰胆碱酯酶维持的直接神经营养作用。
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6944-7. doi: 10.1073/pnas.84.19.6944.
10
L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.L-谷氨酸，一种在猫节前去神经支配的颈上神经节中维持乙酰胆碱酯酶和丁酰胆碱酯酶的神经营养因子。
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2751-4. doi: 10.1073/pnas.83.8.2751.