猫神经组织中乙酰胆碱酯酶和丁酰胆碱酯酶分子形式的分布
Distributions of molecular forms of acetylcholinesterase and butyrylcholinesterase in nervous tissue of the cat.
作者信息
Koelle G B, Massoulié J, Eugène D, Melone M A, Boulla G
机构信息
Laboratoire de Neurobiologie, Ecole Normale Supérieure, Paris, France.
出版信息
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7749-52. doi: 10.1073/pnas.84.21.7749.
Abstract
We analyzed the activities of acetylcholinesterase and butyrylcholinesterase, and of the metabolic enzymes enolase and lactate dehydrogenase, in the superior cervical ganglion, ciliary ganglion, dorsal root ganglion, stellate ganglion, and caudate nucleus of the cat; we found that these tissues possess very different levels of enzymic activities. The proportions of the alpha alpha, alpha gamma, and gamma gamma enolase isozymes are also quite variable. We particularly studied the molecular forms of acetylcholinesterase and butyrylcholinesterase, in normal tissues and in preganglionically denervated SCG, in comparison with earlier histochemical findings. The results are consistent with the premise that the G1 (globular monomer) forms of both enzymes are located in the cytoplasm, the G4 (globular tetramer) forms are at the plasma membranes, and the A12 (collagen-tailed, asymmetric dodecamer) form of acetylcholinesterase is at synaptic sites.
摘要
我们分析了猫的颈上神经节、睫状神经节、背根神经节、星状神经节和尾状核中乙酰胆碱酯酶、丁酰胆碱酯酶以及代谢酶烯醇化酶和乳酸脱氢酶的活性；我们发现这些组织具有非常不同的酶活性水平。αα、αγ和γγ烯醇化酶同工酶的比例也相当多变。与早期的组织化学研究结果相比，我们特别研究了正常组织和节前去神经支配的颈上神经节中乙酰胆碱酯酶和丁酰胆碱酯酶的分子形式。结果与以下前提一致，即这两种酶的G1（球状单体）形式位于细胞质中，G4（球状四聚体）形式位于质膜上，而乙酰胆碱酯酶的A12（胶原尾不对称十二聚体）形式位于突触部位。
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