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COVID-19 对老年人的影响以及意大利疫情早期长期护理机构的作用。

Impact of COVID-19 on older adults and role of long-term care facilities during early stages of epidemic in Italy.

机构信息

Community of Sant'Egidio, Piazza della Nunziata 4, 16124, Genova, Italy.

Biomedicine and Prevention Department, University of Rome "Tor Vergata", Rome, Italy.

出版信息

Sci Rep. 2021 Jun 15;11(1):12530. doi: 10.1038/s41598-021-91992-9.

Abstract

Older adults are the main victims of the novel COVID-19 coronavirus outbreak and elderly in Long Term Care Facilities (LTCFs) are severely hit in terms of mortality. This paper presents a quantitative study of the impact of COVID-19 outbreak in Italy during first stages of the epidemic, focusing on the effects on mortality increase among older adults over 80 and its correlation with LTCFs. The study of growth patterns shows a power-law scaling regime for the first stage of the pandemic with an uneven behaviour among different regions as well as for the overall mortality increase according to the different impact of COVID-19. However, COVID-19 incidence rate does not fully explain the differences of mortality impact in older adults among different regions. We define a quantitative correlation between mortality in older adults and the number of people in LTCFs confirming the tremendous impact of COVID-19 on LTCFs. In addition a correlation between LTCFs and undiagnosed cases as well as effects of health system dysfunction is also observed. Our results confirm that LTCFs did not play a protective role on older adults during the pandemic, but the higher the number of elderly people living in LTCFs the greater the increase of both general and COVID-19 related mortality. We also observed that the handling of the crises in LTCFs hampered an efficient tracing of COVID-19 spread and promoted the increase of deaths not directly attributed to SARS-CoV-2.

摘要

老年人是新型冠状病毒爆发的主要受害者,长期护理机构(LTCF)中的老年人在死亡率方面受到严重冲击。本文对意大利在疫情早期爆发的 COVID-19 进行了定量研究,重点研究了 COVID-19 对 80 岁以上老年人死亡率增加的影响及其与 LTCF 的相关性。研究表明,在大流行的第一阶段,增长模式呈幂律标度,不同地区的行为不均,以及根据 COVID-19 不同的影响,总死亡率增加的情况也不均。然而,COVID-19 发病率并不能完全解释不同地区老年人死亡率差异的原因。我们定义了一个定量相关性,将老年人的死亡率与 LTCF 中的人数联系起来,证实了 COVID-19 对 LTCF 的巨大影响。此外,还观察到 LTCF 与未确诊病例之间的相关性以及卫生系统功能障碍的影响。我们的研究结果证实,在疫情期间,LTCF 并没有对老年人起到保护作用,但是居住在 LTCF 中的老年人数量越多,普通人群和与 COVID-19 相关的死亡率增加的幅度就越大。我们还观察到,LTCF 危机的处理阻碍了 COVID-19 传播的有效追踪,并导致与 SARS-CoV-2 无关的死亡人数增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/050f/8206111/1a5a5eb606dd/41598_2021_91992_Fig1_HTML.jpg

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