Franklin R
South Med J. 1978 Feb;71(2):141-3. doi: 10.1097/00007611-197802000-00017.
There were 150 patients with mycologically proven vulvovaginal candidiasis in a randomized, non-cross-over study which compared seven-and 14-day treatment courses of clotrimazole vaginal tablets (Gyne-Lotrimin) with a 14-day treatment course of miconazole nitrate 2% vaginal cream (Monistat). Adequate data for analyses were obtained for 117 patients. When patients were reexamined four or more weeks after completion of therapy, success rates, based on clinical and mycologic criteria, were: 88% for patients treated with clotrimazole for seven days, 84% for clotrimazole 14-day treatment, and 78% for miconazole nitrate 14-day treatment. There were no drug-related adverse reactions. Thus a seven-day course of therapy with clotrimazole is effective as is a 14-day course of either clotrimazole or miconazole nitrate 2% for the treatment of Candida vaginitis. Statistical analysis revealed no significant differences among the clotrimazole seven-and 14-day treatment groups and the miconazole nitrate 14-day treatment group. The shorter period of administration required for this new antifungal agent should result in better patient compliance and an improved success rate in the rate in the treatment of this frequently encountered infection.
在一项随机、非交叉研究中，有150例经真菌学证实的外阴阴道念珠菌病患者，该研究比较了克霉唑阴道片（Gyne-Lotrimin）7天和14天的治疗疗程与2%硝酸咪康唑阴道乳膏（Monistat）14天的治疗疗程。117例患者获得了充分的分析数据。当患者在完成治疗四周或更长时间后复查时，根据临床和真菌学标准，成功率分别为：接受克霉唑治疗7天的患者为88%，克霉唑治疗14天的患者为84%，2%硝酸咪康唑治疗14天的患者为78%。未出现与药物相关的不良反应。因此，克霉唑7天疗程的治疗效果与克霉唑或2%硝酸咪康唑14天疗程治疗念珠菌性阴道炎的效果相同。统计分析显示，克霉唑7天和14天治疗组与2%硝酸咪康唑14天治疗组之间无显著差异。这种新型抗真菌药物所需的给药时间较短，应能提高患者的依从性，并提高这种常见感染的治疗成功率。
