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一名产科患者在输注来自未输血男性献血者的新鲜冰冻血浆后发生严重的抗体介导的输血相关急性肺损伤。

Severe antibody-mediated transfusion-related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non-transfused male blood donor.

作者信息

Agergaard Charlotte Nielsen, Haunstrup Thure Mors, Fjordside Anne-Louise, Baech John, Steffensen Rudi, Nielsen Kaspar René

机构信息

Department of Clinical Immunology Odense University Hospital Odense Denmark.

Department of Clinical Microbiology Vejle Hospital University Hospital of Southern Denmark Vejle Denmark.

出版信息

Clin Case Rep. 2021 Jun 10;9(6):e03818. doi: 10.1002/ccr3.3818. eCollection 2021 Jun.

DOI:10.1002/ccr3.3818
PMID:34136223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8190689/
Abstract

Transfusion-Related Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of life-threatening TRALI in an obstetric patient triggered by transfusion from a non-transfused male blood donor. A residual risk of TRALI exist, even in a male-only plasma setting.

摘要

输血相关急性肺损伤（TRALI）与输注血液制品中的中性粒细胞反应性抗体有关。我们报告了一例产科患者发生危及生命的TRALI，由未接受过输血的男性献血者的输血引发。即使在仅使用男性血浆的情况下，TRALI仍存在残余风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aa4/8190689/07c184f4371e/CCR3-9-e03818-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aa4/8190689/83c91edaae6c/CCR3-9-e03818-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aa4/8190689/07c184f4371e/CCR3-9-e03818-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aa4/8190689/83c91edaae6c/CCR3-9-e03818-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aa4/8190689/07c184f4371e/CCR3-9-e03818-g002.jpg

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How I treat patients with massive hemorrhage.我如何治疗大出血患者。
Blood. 2014 Nov 13;124(20):3052-8. doi: 10.1182/blood-2014-05-575340. Epub 2014 Oct 7.
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Frequencies of HNA-1, HNA-3, HNA-4, and HNA-5 in the Danish and Zambian populations determined using a novel TaqMan real time polymerase chain reaction method.采用新型TaqMan实时聚合酶链反应方法测定丹麦和赞比亚人群中HNA-1、HNA-3、HNA-4和HNA-5的频率。
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The pathogenesis of transfusion-related acute lung injury (TRALI).输血相关急性肺损伤（TRALI）的发病机制。
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