Is Penicillin-Nonsusceptible a Significant Challenge to Healthcare System? A Systematic Review and Meta-Analysis.

BACKGROUND

In recent years, antibiotic-resistant pathogens including penicillin-nonsusceptible (PNSP) have posed serious threats against human health. The aim of this meta-analysis was to investigate the prevalence of drug resistance particularly the incidence of PNSP strains in Iran.

METHODS

A systematic search was done in national and international electronic databases using Persian and English keywords. Up until May 20, 2020, a total of 58 publications were detected as eligible articles based on the inclusion and exclusion criteria, and then the selected studies were enrolled for data extraction and meta-analysis according to the PRISMA guidelines.

RESULTS

A high rate of PNSP (46.9%) and multidrug-resistant (MDR) (45.3%) in our isolates were evident. Furthermore, total frequency resistance to other drugs in was as follows: erythromycin 41.1%, azithromycin 53.2%, tetracycline 39.9%, levofloxacin 1.7%, rifampin 1.2%, clindamycin 31.7%, vancomycin 1.7%, trimethoprim/sulfamethoxazole 63.9%, chloramphenicol 20%, ceftriaxone 10.9%, amoxicillin 30.5%, ciprofloxacin 8.3%, imipenem 6.1%, linezolid 0%, and cefotaxime 8.3%.

CONCLUSION

Although the overall prevalence of cephalosporin- and carbapenem-resistant was low, penicillin-resistant strains, especially PNSP, could become a significant challenge to the healthcare system in Iran. Hence, the prescription of penicillin as the first-choice antibiotic in the treatment of infections should be avoided.