Antibiotic Resistance of in the Nasopharynx of Healthy Children Less than Five Years Old after the Generalization of Pneumococcal Vaccination in Marrakesh, Morocco.

() remains one of the most important pathogens causing childhood infections. The spread of antibiotic-resistant bacteria is a leading cause of treatment failure in children. The purpose of this investigation is to report the antibiotic and multidrug resistance (MDR) of strains isolated from healthy children throughout the years 2020-2022. Antimicrobial susceptibility testing of strains in selected antimicrobials was performed using disk diffusion and E-test methods on bloodMueller-Hinton agar. The antimicrobials tested included oxacillin, amoxicillin, ceftriaxone, norfloxacin, gentamicin, vancomycin, erythromycin, clindamycin, pristinamycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole. A total of 201 strains were isolated from the nasopharynx of healthy children in Marrakesh, Morocco. The highest rate of resistance of was found in penicillin (57.2%), followed by tetracycline (20.9%), and erythromycin (17.9%). The rates of resistance to clindamycin, trimethoprim-sulfamethoxazole, and chloramphenicol were 14.9%, 4%, and 1.5%, respectively. All isolates were susceptible to norfloxacin, gentamicin, vancomycin, and pristinamycin. Approximately 17% of all strains were resistant to at least three different antibiotic families. This study showed a low rate of antibiotics resistance among nasopharyngeal strains, and it is thus essential to monitor susceptibility in healthy children.