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癌症患者中与新冠病毒疫苗接种相关的新出现问题。

Emerging issues related to COVID-19 vaccination in patients with cancer.

作者信息

Saini Kamal S, Martins-Branco Diogo, Tagliamento Marco, Vidal Laura, Singh Navneet, Punie Kevin, Saini Monika Lamba, Chico Isagani, Curigliano Giuseppe, de Azambuja Evandro, Lambertini Matteo

机构信息

Covance Inc, Princeton, NJ, USA.

, 77 Avenue Marcel Thiry, 1200, Brussels, Belgium.

出版信息

Oncol Ther. 2021 Dec;9(2):255-265. doi: 10.1007/s40487-021-00157-1. Epub 2021 Jun 16.

DOI:10.1007/s40487-021-00157-1
PMID:34137014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8208766/
Abstract

Coronavirus disease 2019 (COVID-19) has resulted in millions of deaths globally. The pandemic has had a severe impact on oncology care and research. Patients with underlying cancer are more vulnerable to contracting COVID-19, and also have a more severe clinical course following the infection. The rollout of COVID-19 vaccines in many parts of the world has raised hopes of controlling the pandemic. In this editorial, the authors outline key characteristics of the currently approved COVID-19 vaccines, provide a brief overview of key emerging issues such as vaccine-induced immune thrombotic thrombocytopenia and SARS-CoV-2 variants of concern, and review the available data related to the efficacy and side effects of vaccinating patients with cancer.

摘要

2019年冠状病毒病(COVID-19)已在全球造成数百万人死亡。这场大流行对肿瘤护理和研究产生了严重影响。患有基础癌症的患者更容易感染COVID-19,并且在感染后临床病程也更严重。世界许多地区推出COVID-19疫苗带来了控制大流行的希望。在这篇社论中,作者概述了目前已获批的COVID-19疫苗的关键特征,简要介绍了诸如疫苗诱导的免疫性血栓性血小板减少症和值得关注的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)变体等关键新出现问题,并回顾了与癌症患者接种疫苗的疗效和副作用相关的现有数据。

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本文引用的文献

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Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis.实体瘤或血液系统恶性肿瘤合并 SARS-CoV-2 感染的成年患者的死亡率:一项系统评价和荟萃分析,重点关注肺癌和乳腺癌。
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Mix-and-match COVID vaccines trigger potent immune response.混合搭配新冠疫苗引发强烈免疫反应。
Nature. 2021 May;593(7860):491. doi: 10.1038/d41586-021-01359-3.
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Heterologous prime-boost COVID-19 vaccination: initial reactogenicity data.异源初免-加强型新型冠状病毒肺炎疫苗接种:初始反应原性数据
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COVID-19 Vaccines in Patients With Cancer-A Welcome Addition, but There Is Need for Optimization.癌症患者的新冠疫苗——一项受欢迎的补充,但仍需优化。
JAMA Oncol. 2021 Aug 1;7(8):1113-1114. doi: 10.1001/jamaoncol.2021.1218.
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Challenges of Cellular Therapy During the COVID-19 Pandemic.2019冠状病毒病大流行期间细胞治疗面临的挑战
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The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.新冠病毒谜题:解析新疾病实体的病理生理学和表型。
Lancet Respir Med. 2021 Jun;9(6):622-642. doi: 10.1016/S2213-2600(21)00218-6. Epub 2021 May 6.
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Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study.丹麦和挪威接种牛津-阿斯利康 ChAdOx1-S 后动脉事件、静脉血栓栓塞、血小板减少和出血:基于人群的队列研究。
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