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新冠疫情期间乳腺癌诊断延误及其临床后果。

Delay in breast cancer diagnosis and its clinical consequences during the coronavirus disease pandemic.

机构信息

Department of General Surgery, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.

出版信息

J Surg Oncol. 2021 Sep;124(3):261-267. doi: 10.1002/jso.26581. Epub 2021 Jun 17.


DOI:10.1002/jso.26581
PMID:34137039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8426951/
Abstract

OBJECTIVE: At the end of 1 year of the coronavirus disease (COVID-19) pandemic, we aimed to reveal the changes in breast cancer cases in the context of cause and effect based on the data of surgically treated patients in our institution. PATIENTS AND METHODS: Patients with breast cancer were divided into two groups. Group 1 consisted of patients who were operated in the year before the COVID-19 pandemic, and Group 2 consisted of patients who were operated within the first year of the pandemic. Tumor size, axillary lymph node positivity, distant organ metastasis status, neoadjuvant chemotherapy, and type of surgery performed were compared between the two groups. RESULTS: The tumor size, axillary lymph node positivity, and neoadjuvant chemotherapy were higher in Group 2 than in Group 1 (p = .005, p = .012, p = .042, respectively). In addition, the number of breast-conserving surgery + sentinel lymph node biopsy were lower, while the number of mastectomy and modified radical mastectomy were higher in Group 2 than in Group 1 (p = .034). CONCLUSION: Patients presented with larger breast tumors and increased axillary involvement during the pandemic. Moreover, distant organ metastases may increase in the future.

摘要

目的:在冠状病毒病(COVID-19)大流行的第 1 年末,我们旨在根据我院手术治疗患者的数据,从因果关系的角度揭示乳腺癌病例的变化。

患者和方法:将乳腺癌患者分为两组。第 1 组包括在 COVID-19 大流行前一年接受手术的患者,第 2 组包括在大流行的第一年接受手术的患者。比较两组患者的肿瘤大小、腋窝淋巴结阳性、远处器官转移状态、新辅助化疗和手术类型。

结果:第 2 组的肿瘤大小、腋窝淋巴结阳性和新辅助化疗均高于第 1 组(p=0.005,p=0.012,p=0.042)。此外,保乳手术+前哨淋巴结活检的数量较低,而第 2 组的乳房切除术和改良根治性乳房切除术数量高于第 1 组(p=0.034)。

结论:在大流行期间,患者的乳房肿瘤更大,腋窝受累增加。此外,未来可能会出现更多的远处器官转移。

相似文献

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Delay in breast cancer diagnosis and its clinical consequences during the coronavirus disease pandemic.

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[2]
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[4]
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[5]
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[7]
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[10]
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本文引用的文献

[1]
The COVID-19 pandemic and impact on breast cancer diagnoses: what happened in England in the first half of 2020.

Br J Cancer. 2021-2

[2]
Effects of the COVID-19 pandemic on breast cancer screening in Taiwan.

Breast. 2020-12

[3]
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In Vivo. 2020

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Breast imaging, breast surgery, and cancer genetics in the age of COVID-19.

Cancer. 2020-8-4

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Effect of delays in the 2-week-wait cancer referral pathway during the COVID-19 pandemic on cancer survival in the UK: a modelling study.

Lancet Oncol. 2020-7-20

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The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study.

Lancet Oncol. 2020-7-20

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Breast Cancer Diagnosis in Coronavirus-Era: Alert From Italy.

Front Oncol. 2020-5-22

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Tor Vergata University-Hospital in the Beginning of COVID-19-Era: Experience and Recommendation for Breast Cancer Patients.

In Vivo. 2020-6

[9]
Breast Cancer and COVID-19: The Effect of Fear on Patients' Decision-making Process.

In Vivo. 2020-6

[10]
ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer.

ESMO Open. 2020-5

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