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将己糖胺酶A的α亚基、甘露糖磷酸异构酶和丙酮酸激酶的结构基因定位于人类15号染色体的q22-qter区域。

Assignment of the structural genes for the alpha subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15.

作者信息

Chern C J, Kennett R, Engel E, Mellman W J, Croce C M

出版信息

Somatic Cell Genet. 1977 Nov;3(6):553-60. doi: 10.1007/BF01539065.

DOI:10.1007/BF01539065
PMID:341373
Abstract

Concordant segregation of the expression of the alpha subunit of human hexosaminidase A, human mannosephosphate isomerase, and pyruvate kinase was observed in somatic cell hybrids between either thymidine kinase-deficient mouse cells or thymidine kinase-deficient Chinese hamster cells and human white blood cells carrying a translocation of the distal half (q 22-qter) of the long arm of chromosome 15 to chromosome 17. A positive correlation was established between the expression of these human phenotypes and the presence of the distal half of the long arm of human chromosome 15.

摘要

在胸苷激酶缺陷型小鼠细胞或胸苷激酶缺陷型中国仓鼠细胞与携带15号染色体长臂远端一半(q22 - qter)易位至17号染色体的人白细胞之间的体细胞杂种中,观察到人类己糖胺酶A的α亚基、人类甘露糖磷酸异构酶和丙酮酸激酶的表达呈一致分离。这些人类表型的表达与人类15号染色体长臂远端一半的存在之间建立了正相关。

相似文献

1
Assignment of the structural genes for the alpha subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15.将己糖胺酶A的α亚基、甘露糖磷酸异构酶和丙酮酸激酶的结构基因定位于人类15号染色体的q22-qter区域。
Somatic Cell Genet. 1977 Nov;3(6):553-60. doi: 10.1007/BF01539065.
2
Localization of MPI, PKM2, IDHM, and the alpha subunit of hexosaminidase (HEXA) to the q21 leads to qter region of human chromosome 15.肌酸激酶同工酶(MPI)、丙酮酸激酶M2型(PKM2)、异柠檬酸脱氢酶(IDHM)和己糖胺酶α亚基(HEXA)定位于人类染色体15的q21至qter区域。
Cytogenet Cell Genet. 1978;22(1-6):503-5. doi: 10.1159/000131008.
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Regional assignment of genes for mannose phosphate isomerase, pyruvate kinase-3, and beta 2-microglobulin expression on human chromosome 15 by hybridization of cells from a t(15;22) (q14;q13.3) translocation carrier.通过对一名t(15;22)(q14;q13.3)易位携带者的细胞进行杂交,将磷酸甘露糖异构酶、丙酮酸激酶-3和β2-微球蛋白表达相关基因定位到人类15号染色体上。
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Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2).己糖胺酶B定位于5号染色体、经白喉毒素筛选后的分离情况以及己糖胺酶A、磷酸甘露糖异构酶和丙酮酸激酶(M2)的连锁关系
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Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2).己糖胺酶B定位于5号染色体、经白喉毒素选择后的分离以及己糖胺酶A、磷酸甘露糖异构酶和丙酮酸激酶(M2)的连锁关系
Birth Defects Orig Artic Ser. 1976;12(7):188-91.
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Assignment of the human genes for mannose phosphate isomerase, pyruvate kinase (M2), and hexosaminidase-A to chromosome 15.将人类磷酸甘露糖异构酶、丙酮酸激酶(M2)和氨基己糖苷酶A的基因定位于15号染色体。
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Human gene mapping using an X/autosome translocation.利用X/常染色体易位进行人类基因定位
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Assignment of the human genes for mannose phosphate isomerase, pyruvate kinase (M2), and hexosaminidase-A to chromosome 15.将人类磷酸甘露糖异构酶、丙酮酸激酶(M2)和氨基己糖苷酶A的基因定位于15号染色体。
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