Kolomaznik M, Komzák F, Haloupková L, Seidl I, Hronek J
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(4):108-10.
The authors have studied early brain stem auditory evoked potentials (EPs) registered after a single intramuscular administration of 2.5 mg of haloperidol in 32 healthy volunteers and 14 schizophrenic patients. Haloperidol led to a significant decrease in the latency of wave V of brain stem auditory EPs in patients with schizophrenia and to its increase in normal subjects. A diminution in wave V of brain stem auditory EPs directly correlated with a reduction of psychopathology expressed in points of the Overall-Gorham scale (BPRS) and observed after one-month haloperidol treatment. The authors discuss the possibility of using changes in brain stem auditory EPs after a single administration of various psychotropics to select an optimal drug for a given patient and also as a possible supplementary diagnostic criterion.
作者对32名健康志愿者和14名精神分裂症患者单次肌肉注射2.5毫克氟哌啶醇后记录的早期脑干听觉诱发电位（EPs）进行了研究。氟哌啶醇使精神分裂症患者脑干听觉EPs的V波潜伏期显著缩短，而使正常受试者的V波潜伏期延长。脑干听觉EPs的V波减小与经一个月氟哌啶醇治疗后用总体-戈尔曼量表（BPRS）评分所表达的精神病理学减轻直接相关。作者讨论了单次给予各种精神药物后利用脑干听觉EPs的变化为特定患者选择最佳药物以及作为一种可能的辅助诊断标准的可能性。
