Schlör K H, Moises H W, Haas S, Rieger H
Pharmacopsychiatry. 1985 Sep;18(5):293-6. doi: 10.1055/s-2007-1017383.
Auditory cortical evoked potentials of 20 schizophrenic patients with an acute exacerbation of the illness were investigated before neuroleptic medication and after remission of the acute symptoms, and compared with healthy controls matched for sex and age. Additionally, tests were conducted in 40 healthy volunteers to ascertain whether psychoticism or other personality factors were correlated with evoked potentials. The aim of the study was to test the overarousal hypothesis of schizophrenia and to control the effects of clinical state, neuroleptic medication and personality factors. Acutely ill schizophrenic patients had a shorter evoked potential N1 latency (Table 1). After remission of the symptoms under haloperidol N1 latency of the patients was no longer different from that of the controls. Patients after remission and on medication, however, had longer P2 and N2 latencies and a greater P2-N2 amplitude (Table 2). Psychoticism and extraversion were correlated negatively with amplitude data of components N1 and P2 in healthy volunteers. The results favor the overarousal hypothesis of schizophrenia. Haloperidol normalizes N1 latency in acutely ill patients. It's effect on later components of the evoked potentials seems comparable to a reduction in vigilance. Auditory evoked potentials might allow to follow up the effect of neuroleptics in acute schizophrenia. It seems necessary to consider personality factors when comparing patients with healthy controls in evoked potential studies.
对20例精神分裂症急性加重期患者在使用抗精神病药物治疗前及急性症状缓解后进行听觉皮层诱发电位研究，并与年龄和性别相匹配的健康对照者进行比较。此外，对40名健康志愿者进行测试，以确定精神病性或其他人格因素是否与诱发电位相关。本研究的目的是检验精神分裂症的过度觉醒假说，并控制临床状态、抗精神病药物治疗和人格因素的影响。急性发病的精神分裂症患者诱发电位N1潜伏期较短（表1）。在氟哌啶醇治疗症状缓解后，患者的N1潜伏期与对照组不再有差异。然而，症状缓解并接受药物治疗的患者P2和N2潜伏期较长，P2-N2波幅较大（表2）。在健康志愿者中，精神病性和外向性与N1和P2成分的波幅数据呈负相关。结果支持精神分裂症的过度觉醒假说。氟哌啶醇可使急性发病患者的N1潜伏期恢复正常。它对诱发电位后期成分的影响似乎与警觉性降低相当。听觉诱发电位可能有助于追踪抗精神病药物在急性精神分裂症中的疗效。在诱发电位研究中比较患者与健康对照者时，似乎有必要考虑人格因素。
