McLennan P L, Abeywardena M Y, Charnock J S
C.S.I.R.O. Division of Human Nutrition, Glenthorne Laboratory,SA, Australia.
Am Heart J. 1988 Sep;116(3):709-17. doi: 10.1016/0002-8703(88)90328-6.
Coronary artery occlusion and reperfusion in the anesthetized rat was used as a whole animal model of arrhythmia and sudden cardiac death to examine the influence of long-term dietary lipid modulation of myocardial membrane fatty acids on the development of cardiac arrhythmias. Feeding rats a diet supplemented with tuna fish oil significantly reduced the incidence and severity of arrhythmias, preventing ventricular fibrillation during both occlusion and reperfusion. Dietary sunflower seed oil reduced arrhythmias during occlusion but not in reperfusion. Dietary fat can modify the vulnerability of the myocardium to arrhythmic stimuli. The efficacy of tuna fish oil in reducing vulnerability to both ischemic and reperfusion arrhythmias suggests a potential beneficial effect of dietary n-3 fatty acids in addition to their influence on hemostasis, plasma lipids, and atherosclerosis that may contribute to their proposed role in lowering cardiovascular disease mortality and morbidity.
在麻醉大鼠中进行冠状动脉闭塞和再灌注，以此作为心律失常和心源性猝死的整体动物模型，来研究长期饮食脂质调节心肌膜脂肪酸对心律失常发生发展的影响。给大鼠喂食添加金枪鱼鱼油的饮食可显著降低心律失常的发生率和严重程度，在闭塞和再灌注期间均可预防心室颤动。喂食向日葵籽油的饮食可降低闭塞期间的心律失常，但再灌注期间则无此效果。饮食脂肪可改变心肌对心律失常刺激的易感性。金枪鱼鱼油在降低对缺血性和再灌注性心律失常的易感性方面的功效表明，饮食中的n-3脂肪酸除了对止血、血脂和动脉粥样硬化有影响外，可能还有潜在的有益作用，这些影响可能有助于其在降低心血管疾病死亡率和发病率方面所提出的作用。
