大脑结构与 ABCD 研究中儿童家庭环境与行为问题之间的关联有关。

Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.

Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.

Nat Commun. 2021 Jun 18;12(1):3769. doi: 10.1038/s41467-021-23994-0.

Children's behavioral problems have been associated with their family environments. Here, we investigate whether specific features of brain structures could relate to this link. Using structural magnetic resonance imaging of 8756 children aged 9-11 from the Adolescent Brain Cognitive Developmental study, we show that high family conflict and low parental monitoring scores are associated with children's behavioral problems, as well as with smaller cortical areas of the orbitofrontal cortex, anterior cingulate cortex, and middle temporal gyrus. A longitudinal analysis indicates that psychiatric problems scores are associated with increased family conflict and decreased parental monitoring 1 year later, and mediate associations between the reduced cortical areas and family conflict, and parental monitoring scores. These results emphasize the relationships between the brain structure of children, their family environments, and their behavioral problems.

儿童的行为问题与其家庭环境有关。在这里，我们研究了大脑结构的特定特征是否与这一联系有关。我们利用来自青少年大脑认知发育研究的 8756 名 9-11 岁儿童的结构磁共振成像，表明高家庭冲突和低父母监督分数与儿童的行为问题有关，还与眶额皮层、前扣带皮层和中颞叶的皮质面积较小有关。一项纵向分析表明，1 年后精神问题评分与家庭冲突增加和父母监督减少有关，并且在皮质面积减少与家庭冲突和父母监督评分之间的关联中起中介作用。这些结果强调了儿童的大脑结构、家庭环境和行为问题之间的关系。