State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, 14# Third Section, Renmin Nan Road, Chengdu, 610041, China.
Stem Cell Res Ther. 2021 Jun 19;12(1):357. doi: 10.1186/s13287-021-02446-y.
The dentin-pulp complex is essential for the long-term integrity and viability of teeth but it is susceptible to damage caused by external factors. Because traditional approaches for preserving the dentin-pulp complex have various limitations, there is a need for novel methods for dentin-pulp complex reconstruction. The development of stem cell-based tissue engineering has given rise to the possibility of combining dental stem cells with a tissue-reparative microenvironment to promote dentin-pulp complex regeneration. Concentrated growth factor, a platelet concentrate, is a promising scaffold for the treatment of dentin-pulp complex disorders. Given its characteristics of autogenesis, convenience, usability, and biodegradability, concentrated growth factor has gained popularity in medical and dental fields for repairing bone defects and promoting soft-tissue healing. Numerous in vitro studies have demonstrated that concentrated growth factor can promote the proliferation and migration of dental stem cells. Here, we review the current state of knowledge on the effects of concentrated growth factor on stem cells and its potential applications in dentin-pulp complex regeneration.
牙髓复合体对于牙齿的长期完整性和活力至关重要，但它容易受到外部因素的损害。由于传统的保存牙髓复合体的方法存在各种局限性，因此需要新的方法来进行牙髓复合体的重建。基于干细胞的组织工程的发展使得将牙源性干细胞与组织修复微环境相结合以促进牙髓复合体再生成为可能。浓缩生长因子，即血小板浓缩物，是一种有前途的用于治疗牙髓复合体疾病的支架。鉴于其具有自体性、便利性、可用性和生物降解性等特点，浓缩生长因子在医学和牙科领域中用于修复骨缺损和促进软组织愈合方面已经广受欢迎。大量的体外研究表明，浓缩生长因子可以促进牙源性干细胞的增殖和迁移。在这里，我们综述了浓缩生长因子对干细胞的作用及其在牙髓复合体再生中的潜在应用的最新知识。
Zotero 插件
