Sabate J-M, Deutsch D, Melchior C, Entremont A, Mion F, Bouchoucha M, Façon S, Raynaud J-J, Zerbib F, Jouët P
Gastroenterology Department, hôpital Avicenne, Paris 13 Nord, AP-HP, 125, rue de Stalingrad, Bobigny, France.
INSERM U-987, Pathophysiology and Clinical Pharmacology of pain, Ambroise-Paré Hospital, 92100 Boulogne-Billancourt, France.
Ethics Med Public Health. 2021 Sep;18:100660. doi: 10.1016/j.jemep.2021.100660. Epub 2021 Mar 24.
While all resources have been mobilized to fight COVID-19, this study aimed to analyze the consequences of lockdown and pandemic stress in participants with and without Irritable Bowel Syndrome (IBS).
An online survey was proposed to people with or without IBS during the exponential phase of the pandemic in France. The questionnaire included questions about socio-demographic data, conditions of confinement, activities carried out, IBS characteristics, measurement of stress level, consequences on sleep, fatigue, anxiety and depression, and quality of life (both perceived non-specific and specific for IBS).
RESULTS/DISCUSSION: From March 31 to April 15, 2020, 304 participants, 232 with IBS and 72 without were included in the survey (mean age: 46.8 ± 16.8 years, female gender: 75.3%). Age, level of education, financial resources, living space per person and activities performed during confinement were identical in both groups. Stress linked to fear of COVID-19, lockdown and financial worries was at the same level in both groups, but the psychological consequences and deterioration of quality of life (QOL) were both higher in IBS participants. In a univariate analysis, teleworking, solitary confinement, and low household resources had a variable impact on the scores of depression, anxiety, fatigue and non-specific perceived QOL, but in a multivariate analysis, the only factor explaining a deterioration of non-specific QOL was the fact of suffering from IBS.
CONCLUSION/PERSPECTIVES: Stress linked to the COVID-19 pandemic and confinement is high and equivalent in both IBS and non-IBS participants, with higher psychological and QOL consequences in IBS patients who have altered coping capacities.
在调动所有资源抗击新冠疫情之际，本研究旨在分析封锁措施和疫情压力对患有和未患有肠易激综合征（IBS）的参与者的影响。
在法国疫情呈指数级增长阶段，对患有或未患有IBS的人群开展了一项在线调查。问卷包括社会人口统计学数据、隔离条件、进行的活动、IBS特征、压力水平测量、对睡眠、疲劳、焦虑和抑郁的影响以及生活质量（包括总体感知的生活质量和IBS特异性生活质量）等方面的问题。
结果/讨论：2020年3月31日至4月15日，共有304名参与者纳入调查，其中232名患有IBS，72名未患有IBS（平均年龄：46.8±16.8岁，女性占75.3%）。两组在年龄、教育程度、经济资源、人均居住空间以及隔离期间进行的活动方面均相同。与对新冠疫情的恐惧、封锁措施和经济担忧相关的压力在两组中处于同一水平，但IBS参与者的心理后果和生活质量（QOL）恶化程度均更高。在单因素分析中，远程办公、单独隔离和家庭资源匮乏对抑郁、焦虑、疲劳和总体感知QOL评分有不同影响，但在多因素分析中，唯一能解释总体QOL恶化的因素是患有IBS这一事实。
结论/展望：与新冠疫情和封锁措施相关的压力在IBS和非IBS参与者中都很高且相当，但对应对能力已改变的IBS患者而言，其心理影响和生活质量后果更为严重。
