State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Crit Rev Biotechnol. 2022 Feb;42(1):125-144. doi: 10.1080/07388551.2021.1931015. Epub 2021 Jun 20.
Acyltransferases (ATs) are important tailoring enzymes that contribute to the diversity of natural products. They catalyze the transfer of acyl groups to the skeleton, which improves the lipid solubility, stability, and pharmacological activity of natural compounds. In recent years, a number of ATs have been isolated from plants. In this review, we have summarized 141 biochemically characterized ATs during the period July 1997 to October 2020, including their function, heterologous expression systems, and catalytic mechanisms. Their catalytic performance and application potential has been further discussed.
酰基转移酶(ATs)是一类重要的修饰酶,它们有助于天然产物的多样性。它们能够催化酰基基团向骨架的转移,从而提高天然化合物的脂溶性、稳定性和药理学活性。近年来,从植物中分离到了许多 ATs。在本综述中,我们总结了 1997 年 7 月至 2020 年 10 月期间 141 种生化特性明确的 ATs,包括它们的功能、异源表达系统和催化机制。进一步讨论了它们的催化性能和应用潜力。