多领域生活方式干预对估计痴呆风险的影响。
Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk.
机构信息
Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden.
出版信息
J Alzheimers Dis. 2021;82(4):1461-1466. doi: 10.3233/JAD-210331.
Abstract
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
摘要
我们研究了一种多领域生活方式干预对使用经过验证的 CAIDE 风险评分估计的痴呆风险的影响（事后分析）。芬兰老年干预研究以预防认知障碍和残疾（FINGER）是一项为期 2 年的随机对照试验，涉及 1260 名高危老年人（60-77 岁）。与对照组相比，干预组在 2 年内 CAIDE 评分的估计平均变化差异为-0.16（95%CI-0.31 至 0.00）（p=0.013），这对应于相对痴呆风险降低 6.04-6.50%。这可以解释为干预预防潜力的反映。
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本文引用的文献
1
The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People.
J Am Geriatr Soc. 2019 Jun;67(6):1138-1144. doi: 10.1111/jgs.15837. Epub 2019 Feb 26.
2
Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial.
JAMA Neurol. 2018 Apr 1;75(4):462-470. doi: 10.1001/jamaneurol.2017.4365.
3
The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity-the FINGER Randomized Controlled Trial.
J Am Med Dir Assoc. 2018 Apr;19(4):355-360.e1. doi: 10.1016/j.jamda.2017.09.020. Epub 2017 Nov 3.
4
Challenges and recommendations for the health-economic evaluation of primary prevention programmes for dementia.
Aging Ment Health. 2019 Jan;23(1):53-59. doi: 10.1080/13607863.2017.1390730. Epub 2017 Oct 17.
5
Defeating Alzheimer's disease and other dementias: a priority for European science and society.
Lancet Neurol. 2016 Apr;15(5):455-532. doi: 10.1016/S1474-4422(16)00062-4.
6
Current Developments in Dementia Risk Prediction Modelling: An Updated Systematic Review.
PLoS One. 2015 Sep 3;10(9):e0136181. doi: 10.1371/journal.pone.0136181. eCollection 2015.
7
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.
Lancet. 2015 Jun 6;385(9984):2255-63. doi: 10.1016/S0140-6736(15)60461-5. Epub 2015 Mar 12.
8
Statistical evaluation of surrogate endpoints with examples from cancer clinical trials.
Biom J. 2016 Jan;58(1):104-32. doi: 10.1002/bimj.201400049. Epub 2015 Feb 12.
9
Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial.
Int J Environ Res Public Health. 2014 Sep 10;11(9):9345-60. doi: 10.3390/ijerph110909345.
10
Midlife risk score for the prediction of dementia four decades later.
Alzheimers Dement. 2014 Sep;10(5):562-70. doi: 10.1016/j.jalz.2013.05.1772. Epub 2013 Sep 10.
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