Wang Sai, Yan Xiaochen, Yang Yan, Qi Xiaoyan, Zhao Yinglin, Li Ling, Ma Rui, Wang Lele, Dong Yiyang, Sun Jianan, Mao Xiangzhao
College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China.
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Food Chem. 2021 Dec 1;364:130361. doi: 10.1016/j.foodchem.2021.130361. Epub 2021 Jun 15.
The residual tetracyclines in food are frequently applied as the model compounds to develop aptasensors. Until now, more than 100 advanced aptasensors towards tetracyclines have been developed and published in English. This review summarizes and discusses comprehensively these advanced aptasensors, in terms of the principle designs, applied frontier transducers/materials, working performance, and advantages/disadvantages. The aptasensors are classified according to the inherent transduction techniques, i.e., optics, optics-electricity, optics-mass, and electricity-mass. Moreover, the present challenges such as the limited specificity and limited affinity of the aptamers, the future prospects and trends such as further combination with other advanced materials and technologies, and the urgent need of expanding the practical application were discussed and prospected. We hope this review can serve as a powerful tool for both tracing the development progresses of aptasensors and providing adequate references for further development of aptasensing methods for food-related analytes.
食品中的残留四环素常被用作开发适体传感器的模型化合物。截至目前，已开发出100多种针对四环素的先进适体传感器，并以英文发表。本综述全面总结和讨论了这些先进的适体传感器，包括原理设计、应用的前沿换能器/材料、工作性能以及优缺点。适体传感器根据其固有的传感技术进行分类，即光学、光电、光质量和电质量。此外，还讨论并展望了当前存在的挑战，如适体的特异性和亲和力有限；未来的前景和趋势，如与其他先进材料和技术的进一步结合；以及扩大实际应用的迫切需求。我们希望这篇综述既能作为追踪适体传感器发展进展的有力工具，又能为进一步开发用于食品相关分析物的适体传感方法提供充分的参考。
