Valenti A J, Andriole V T
Yale J Biol Med. 1977 Sep-Oct;50(5):465-9.
Cefaclor is an orally absorbed cephalosporin antibiotic chemically and pharmacologically similar to cephalexin. It appears to be more active than cephalexin against susceptible strains. The in vitro sensitivity of 230 clinical bacterial isolates to cefaclor was studied. Most isolates of S. aureus, K. pneumoniae, E. coli, and indole negative Proteus species were inhibited at clinically attainable serum and urine concentrations. Like cephalexin, cefaclor was less active against isolates of Enterobacter species, indole positive Proteus species and enterococci although many of these isolates were inhibited at concentrations achievable in urine.
头孢克洛是一种口服吸收的头孢菌素类抗生素，在化学和药理上与头孢氨苄相似。它对敏感菌株的活性似乎比头孢氨苄更强。对230株临床分离菌进行了头孢克洛的体外敏感性研究。在临床可达到的血清和尿液浓度下，大多数金黄色葡萄球菌、肺炎克雷伯菌、大肠杆菌和吲哚阴性变形杆菌属菌株受到抑制。与头孢氨苄一样，头孢克洛对阴沟肠杆菌属菌株、吲哚阳性变形杆菌属菌株和肠球菌的活性较低，尽管其中许多菌株在尿液中可达到的浓度下受到抑制。
