头孢克洛（一种头孢菌素类抗生素）在三种实验动物体内的代谢情况，其中头孢克洛用（14C）标记 。
Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals.
作者信息
Sullivan H R, Due S L, Kau D L, Quay J F, Miller W
出版信息
Antimicrob Agents Chemother. 1976 Oct;10(4):630-8. doi: 10.1128/AAC.10.4.630.
Abstract
The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated unchanged as unaltered antibiotic, primarily by renal excretion. In dogs, however, cefaclor is more labile to metabolism and only a portion of the administered antibiotic is eliminated unchanged via the kidney.
摘要
已在大鼠、小鼠和犬中研究了口服有效的头孢克洛抗生素（礼来99638）的代谢命运。头孢克洛作为完整的抗生素可从胃肠道有效吸收。在大鼠和小鼠中，头孢克洛在很大程度上在体内逃避代谢，并以未改变的抗生素形式原样排泄，主要通过肾脏排泄。然而，在犬中，头孢克洛对代谢更不稳定，仅一部分给药抗生素通过肾脏原样排泄。
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